| General Information of MIC (ID: MIC01246) |
| MIC Name |
Streptococcus cristatus (firmicutes)
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| MIC Synonyms |
Streptococcus crista
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| Body Site |
Oral Cavity
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| Lineage |
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus cristatus
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| Oxygen Sensitivity |
Facultative anaerobe
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| Microbial Metabolism |
Saccharolytic; Respiratory or Fermentative
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| Gram |
Positive
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| Host Relationship |
Commensal
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| Genome Size (bp) |
1982490
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| No. of Coding Genes |
1924
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| No. of Non-Coding Genes |
80
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| No. of Small Non-Coding Genes |
80
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| No. of Gene Transcripts |
2004
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| No. of Base Pairs |
2026543
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| Description |
Streptococcus cristatus is a species of viridans Streptococcus with tufted fibrils, first isolated from the human oral cavity and throat.
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| External Links |
Taxonomy ID |
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| Genome Assembly ID |
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| GOLD Organism ID |
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| Disease Relevance |
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| Tooth pulp necrosis [ICD-11: DA01] |
| Description |
Streptococcus cristatus was associated with tooth decay. |
[1] |
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| Host Genetic Factors (HGFs) |
| rs60977619 |
| HGF ID |
HGF2103 |
HGF Info
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Class |
Single Nucleotide Polymorphism (SNP) |
| Description |
The rs60977619 SNP was significantly associated with the abundance of Streptococcus oligofermentans (p-value<1.00E-08). |
[2] |
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| Host Immune Factors (HIFs) |
| Interleukin-1 alpha |
| HIF ID |
HIFM0137 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
The RT-PCR confirmed the messenger RNA attenuation of IL-1alpha by Streptococcus cristatus. |
[3] |
| Interferon-6 |
| HIF ID |
HIFM0151 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
The RT-PCR confirmed the messenger RNA attenuation of IL-6 by Streptococcus cristatus. |
[3] |
| Tumor necrosis factor |
| HIF ID |
HIFM0226 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
The RT-PCR confirmed the messenger RNA attenuation of IL-1Alpha, tumor necrosis factor-Alpha and IL-6 by Streptococcus cristatus. |
[3] |
| Nuclear factor kappa B signaling pathway |
| HIF ID |
HIFP0028 |
HIF Info
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Class |
Signaling pathway (SP) |
| Description |
Streptococcus cristatus attenuates Fusobacterium nucleatum-induced cytokine expression by influencing pathways converging on nuclear factor-kappaB. |
[3] |
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| Environmental Factor(s) |
| Disbiome ID |
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| gutMDisorder ID |
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| References |
| 1 |
Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay. ISME J. 2018 Sep;12(9):2292-2306. doi: 10.1038/s41396-018-0204-z. Epub 2018 Jun 13.
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| 2 |
Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
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| 3 |
Streptococcus cristatus attenuates Fusobacterium nucleatum-induced cytokine expression by influencing pathways converging on nuclear factor-B. Mol Oral Microbiol. 2011 Apr;26(2):150-63. doi: 10.1111/j.2041-1014.2010.00600.x. Epub 2011 Jan 27.
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