Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01322)
MIC Name Treponema denticola (spirochetes)
MIC Synonyms Spirochaete denticola
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Spirochaetes
Class: Spirochaetia
Order: Spirochaetales
Family: Spirochaetaceae
Genus: Treponema
Species: Treponema denticola
Oxygen Sensitivity Anaerobe
Microbial Metabolism Fermentative
Gram Negative
Host Relationship Pathogen
Description Treponema denticola is a Gram-negative bacterium from the Spirochetes family that is motile, slender, helically shaped and flexible. Treponema denticola is anaerobic and cannot survive in the presence of oxygen.
External Links Taxonomy ID
158
Genome Assembly ID
Trep_dent_ATCC_33520_V1
GOLD Organism ID
Go0286538
Disease Relevance
          Dermatitis and eczema  [ICD-11: EA80]
             Description Treponema denticola was associated with digital dermatitis. [1]
Host Genetic Factors (HGFs)
          hsa-miR-132-3p
             HGF ID HGF0267 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-132 expression was inhibited by Treponema denticola alonely. [2]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-146a expression was inhibited by Treponema denticola alonely. [2]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-155 expression failed to be increased by Treponema denticola. [2]
          rs7818452
             HGF ID HGF1605 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7818452 SNP was significantly associated with the abundance of Treponema denticola (p-value<1.00E-08). [3]
          rs5744080
             HGF ID HGF1271 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs5744080 SNP was significantly associated with the abundance of Treponema denticola (p-value=0.008). [4]
          rs5744077
             HGF ID HGF1272 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs5744077 SNP was significantly associated with the abundance of Treponema denticola (p-value=0.008). [4]
          rs5743810
             HGF ID HGF1273 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs5743810 SNP was significantly associated with the abundance of Treponema denticola (p-value=0.003). [4]
          rs5743795
             HGF ID HGF1274 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs5743795 SNP was significantly associated with the abundance of Treponema denticola (p-value=0.004). [4]
          rs5743618
             HGF ID HGF1290 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs5743618 SNP was significantly associated with the abundance of Treponema denticola (p-value=0.001). [4]
          rs5743595
             HGF ID HGF1291 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs5743595 SNP was significantly associated with the abundance of Treponema denticola (p-value=0.001). [4]
          rs5743551
             HGF ID HGF1292 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description The rs5743551 SNP was significantly associated with the abundance of Treponema denticola (p-value=0.001). [4]
          rs4696480
             HGF ID HGF1288 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4696480 SNP was significantly associated with the abundance of Treponema denticola (p-value=0.006). [4]
          rs305572
             HGF ID HGF1893 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs305572 SNP was significantly associated with the abundance of Treponema denticola (p-value<1.00E-08). [3]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Treponema denticola could stimulate the production of IL-10 through increasing enzyme activity. [5]
          Interferon-12 subunit alpha
             HIF ID HIFM0130 HIF Info       Class Cytokine (Cyt)
             Description Treponema denticola could stimulate the production of IL-12. [5]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Treponema denticola could stimulate the production of IL-1beta. [5]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Treponema denticola could stimulate the production of IL-6. [5]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Treponema denticola could stimulate the production of TNF-Alpha. [5]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description IL-8 neutrophils was recruited to the periodontal pockets, failed secreted when response to Treponema denticola exposure. [6]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Treponema denticola is associated with IgG response. [7]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description Treponema denticola could trigger activation of NF-B. [5]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Treponema denticola stimulates the innate immune system through Toll-like receptor 2 (TLR2). [5]
Environmental Factor(s)
             Disbiome ID
      367
             gutMDisorder ID
      gm0651
References
1 Associations between digital dermatitis lesion grades in dairy cattle and the quantities of four Treponema species. Vet Res. 2018 Oct 29;49(1):111. doi: 10.1186/s13567-018-0605-z.
2 Polymicrobial infection alter inflammatory microRNA in rat salivary glands during periodontal disease. Anaerobe. 2016 Apr;38:70-75. doi: 10.1016/j.anaerobe.2015.10.005. Epub 2015 Oct 22.
3 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
4 Associations of Toll-Like Receptor and -Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study.PLoS One. 2016 Oct 11;11(10):e0164075. doi: 10.1371/journal.pone.0164075. eCollection 2016.
5 Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2. Infect Immun. 2017 Dec 19;86(1):e00573-17. doi: 10.1128/IAI.00573-17. Print 2018 Jan.
6 Human neutrophils and oral microbiota: a constant tug-of-war between a harmonious and a discordant coexistence.Immunol Rev. 2016 Sep;273(1):282-98. doi: 10.1111/imr.12451.
7 Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease.PLoS One. 2014 Dec 18;9(12):e114959. doi: 10.1371/journal.pone.0114959. eCollection 2014.

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