Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00702)
MIC Name Lactobacillus acidophilus (firmicutes)
MIC Synonyms Bacillus acidophilus
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus acidophilus
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 1875071
No. of Coding Genes 1777
No. of Non-Coding Genes 63
No. of Small Non-Coding Genes 63
No. of Gene Transcripts 1840
No. of Base Pairs 1956698
Description Lactobacillus acidophilus is a species of facultatively anaerobic, Gram positive bacterium. L. acidophilus is a probiotic bacteria that naturally occurs in the human gut and other parts of the body.
External Links Taxonomy ID
1579
Genome Assembly ID
ASM78639v1
GOLD Organism ID
Go0037534
Disease Relevance
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Lactobacillus acidophilus was associated with Inflammatory bowel disease. [1]
          Osteoarthritis  [ICD-11: FA0Z]
             Description Lactobacillus acidophilus can alleviate Osteoarthritis-associated pain and delay the progression of the disease by inhibiting proinflammatory cytokine production and reducing cartilage damage. [2]
Host Genetic Factors (HGFs)
          hsa-miR-135b-5p
             HGF ID HGF0264 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-135b expression was 0.56-fold down-regulation in Lactobacillus acidophilus. [3]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-155 expression was 1.36-fold up-regulation in Lactobacillus acidophilus. [3]
          hsa-miR-18a-5p
             HGF ID HGF0238 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-18a expression was 1.36-fold up-regulation in Lactobacillus acidophilus. [3]
          hsa-miR-26b-5p
             HGF ID HGF0183 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-26b expression was 3.6-fold up-regulation in Lactobacillus acidophilus. [3]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The application of Lactobacillus acidophilus KLDS resulted in the down-regulation of miR-146a. [4]
Host Immune Factors (HIFs)
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description The expression of TNF-Alpha in intestinal epithelial cells during Salmonella Typhimurium challenge was decreased by Lactobacillus acidophilus alone or combined with immune active longchain inulin. [5]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description The gene expression of IL6 in IECs could be induced by Lactobacillus acidophilus infection. [5]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description The gene expression of IL8 in IECs was decreased by Lactobacillus acidophilus infection. [5]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Lactobacillus acidophilus W37 infection can induce DCs response. [5]
          Bone marrow-derived dendritic cells
             HIF ID HIFC0166 HIF Info       Class Dendritic cells (DCs)
             Description Endocytosis of Lactobacillus acidophilus NCFM by bone marrow-derived dendritic cells induced interferon beta(IFN-beta) production. [6]
          Toll like receptor 2 signalling pathway
             HIF ID HIFP0044 HIF Info       Class Signaling pathway (SP)
             Description Lactobacillus acidophilus W37 statistically significantly activated TLR2 in a dose dependent way inducing a 1.4 fold increase at 106 CFU mL-1 (p = 0.003) and an 8.2 fold increase (p < 0.0001) at 107 CFU mL-1. [5]
          Toll like receptor 3 signalling pathway
             HIF ID HIFP0045 HIF Info       Class Signaling pathway (SP)
             Description Lactobacillus acidophilus W37 could increase TLR3 at 106 CFU mL-1 (1.2 fold; p = 0.07) and significantly increase reaching 5.5 fold at 107 CFU mL-1 (p = 0.0002). [5]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description At the species level, Lactobacillus acidophilus is associated with NF-B. [5]
          CD103+Helios CD4+CD25+FOXP3+ regulatory T cells
             HIF ID HIFC0186 HIF Info       Class T cells (TCs)
             Description Lactobacillus acidophilus is related to the expansion of colonic CD103+HeliosCD4+CD25+FOXP3+ Treg cell population. [7]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description A subset of CD4+ T cells reactive to Lactobacillus acidophilus could increase the production of the immunoregulatory cytokine IL10 of 7%(p<0.05). [8]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description The stimulatory effects of the Lactobacillus acidophilus could be observed on TLR2. [5]
Environmental Factor(s)
             Disbiome ID
      523
             gutMDisorder ID
      gm0394
References
1 Probiotic Species in the Modulation of Gut Microbiota: An Overview. Biomed Res Int. 2018 May 8;2018:9478630. doi: 10.1155/2018/9478630. eCollection 2018.
2 Lactobacillus acidophilus ameliorates pain and cartilage degradation in experimental osteoarthritis. Immunol Lett. 2018 Nov;203:6-14. doi: 10.1016/j.imlet.2018.07.003. Epub 2018 Jul 9.
3 Expression profiling of peripheral blood miRNA using RNAseq technology in dairy cows with Escherichia coli-induced mastitis. Luoreng ZM, Wang XP, Mei CG, Zan LS.. Sci Rep. 2018 Aug 23;8(1):12693. doi: 10.1038/s41598-018-30518-2.
4 Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1. Vikram A, Kim YR, Kumar S, Li Q, Kassan M, Jacobs JS, Irani K.. Nat Commun. 2016 Sep 2;7:12565. doi: 10.1038/ncomms12565.
5 Synbiotic Effects of the Dietary Fiber Long-Chain Inulin and Probiotic Lactobacillus acidophilus W37 Can be Caused by Direct, Synergistic Stimulation of Immune Toll-Like Receptors and Dendritic Cells. Mol Nutr Food Res. 2018 Jun 14;62(15):e1800251. doi: 10.1002/mnfr.201800251. Online ahead of print.
6 Surface Layer of Lactobacillus helveticus MIMLh5 Promotes Endocytosis by Dendritic Cells.Appl Environ Microbiol. 2019 Apr 18;85(9):e00138-19. doi: 10.1128/AEM.00138-19. Print 2019 May 1.
7 Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.
8 Circulating and Tissue-Resident CD4(+) T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. 2017 Nov;153(5):1320-1337.e16. doi: 10.1053/j.gastro.2017.07.047. Epub 2017 Aug 4.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.