Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0045)
HIF Name
Toll like receptor 3 signalling pathway
HIF Synonym(s)
Toll-like receptor (TLR3) signaling, TLR-3 signalling pathway
HIF Classification
Signaling pathway (SP)
Description TLR3 is the only TLR that uses a MyD88-independent signaling pathway [1]
Microbe Species (MIC) Regulated by This HIF
         Lactobacillus acidophilus (firmicutes) MIC00702
             Description Lactobacillus acidophilus W37 could increase TLR3 at 106 CFU mL-1 (1.2 fold; p = 0.07) and significantly increase reaching 5.5 fold at 107 CFU mL-1 (p = 0.0002). [2]
References
1 The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins.Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2420-30. doi: 10.1107/S0907444913022385. Epub 2013 Nov 19.
2 Synbiotic Effects of the Dietary Fiber Long-Chain Inulin and Probiotic Lactobacillus acidophilus W37 Can be Caused by Direct, Synergistic Stimulation of Immune Toll-Like Receptors and Dendritic Cells. Mol Nutr Food Res. 2018 Jun 14;62(15):e1800251. doi: 10.1002/mnfr.201800251. Online ahead of print.

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