Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00493)
MIC Name Desulfovibrio sp. (delta-proteobacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Deltaproteobacteria
Order: Desulfovibrionales
Family: Desulfovibrionaceae
Genus: Desulfovibrio
Species: Desulfovibrio sp.
Oxygen Sensitivity Anaerobe
Microbial Metabolism Only anaerobic respiration with sulfate as electron acceptor; Nonfermentative; Asaccharolytic
Gram Negative
Host Relationship Commensal
Description Desulfovibrio is a genus of Gram-negative sulfate-reducing bacteria. Desulfovibrio species are commonly found in aquatic environments with high levels of organic material, as well as in water-logged soils.
External Links Taxonomy ID
885
GOLD Organism ID
Go0003645
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description A trend in the incidence of elevated Desulfovibrio spp. in children with autism was reaffirmed by a very strong association of the amount of Desulfovibrio spp. [1]
          Colorectal cancer  [ICD-11: 2B91]
             Description Desulfovibrio was associated with colorectal cancer. [2]
Host Genetic Factors (HGFs)
          AVP
             HGF ID HGF2328 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of AVP could significantly increase relative abundances of Desulfovibrio c21. (p-value<0.05). [3]
          MUC2
             HGF ID HGF2331 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of MUC2 showed increased abundance of Desulfovibrio. [4]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of Desulfovibrio. [5]
          NLRP3
             HGF ID HGF2355 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of NLRP3 could significantly increase the abundance of Desulfovibrio (p-value<0.001). [6]
          rs992900
             HGF ID HGF1551 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs992900 SNP was significantly associated with the abundance of Desulfovibrio (p-value=3.94E-04). [7]
          rs9886211
             HGF ID HGF1755 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs9886211 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.04E-03). [7]
          rs936012
             HGF ID HGF1810 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs936012 SNP was significantly associated with the abundance of Desulfovibrio (p-value=6.72E-04). [7]
          rs830964
             HGF ID HGF1540 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs830964 SNP was significantly associated with the abundance of Desulfovibrio (p-value=6.63E-05). [7]
          rs8020729
             HGF ID HGF2210 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs8020729 SNP was significantly associated with the abundance of Desulfovibrio (p-value=5.06E-06). [7]
          rs7955257
             HGF ID HGF2239 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7955257 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.69E-04). [7]
          rs787665
             HGF ID HGF1492 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs787665 SNP was significantly associated with the abundance of Desulfovibrio (p-value=5.49E-06). [7]
          rs764956
             HGF ID HGF1809 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs764956 SNP was significantly associated with the abundance of Desulfovibrio (p-value=2.75E-04). [7]
          rs753768
             HGF ID HGF2051 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs753768 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.75E-05). [7]
          rs7134941
             HGF ID HGF2237 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7134941 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.69E-04). [7]
          rs6751113
             HGF ID HGF1241 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6751113 SNP was significantly associated with the abundance of Desulfovibrio (p-value=3.30E-04). [7]
          rs6746082
             HGF ID HGF1815 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6746082 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.04E-03). [7]
          rs6546314
             HGF ID HGF1808 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6546314 SNP was significantly associated with the abundance of Desulfovibrio (p-value=5.11E-04). [7]
          rs6531212
             HGF ID HGF2131 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6531212 SNP was significantly associated with the abundance of Desulfovibrio (p-value=4.02E-04). [7]
          rs6463097
             HGF ID HGF1996 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6463097 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.60E-04). [7]
          rs6463094
             HGF ID HGF1997 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6463094 SNP was significantly associated with the abundance of Desulfovibrio (p-value=2.43E-04). [7]
          rs636586
             HGF ID HGF1811 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs636586 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.04E-03). [7]
          rs517403
             HGF ID HGF1812 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs517403 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.04E-03). [7]
          rs4737490
             HGF ID HGF1550 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4737490 SNP was significantly associated with the abundance of Desulfovibrio (p-value=3.36E-04). [7]
          rs4724101
             HGF ID HGF1754 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4724101 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.22E-03). [7]
          rs4684687
             HGF ID HGF1914 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4684687 SNP was significantly associated with the abundance of Desulfovibrio (p-value=3.25E-04). [7]
          rs4614937
             HGF ID HGF1619 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4614937 SNP was significantly associated with the abundance of Desulfovibrio (p-value=2.11E-04). [7]
          rs2299148
             HGF ID HGF1756 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2299148 SNP was significantly associated with the abundance of Desulfovibrio (p-value=2.47E-04). [7]
          rs2068148
             HGF ID HGF1780 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2068148 SNP was significantly associated with the abundance of Desulfovibrio (p-value=5.57E-04). [7]
          rs1965239
             HGF ID HGF1813 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1965239 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.04E-03). [7]
          rs17649894
             HGF ID HGF2110 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17649894 SNP was significantly associated with the abundance of Desulfovibrio (p-value=2.03E-04). [7]
          rs17459026
             HGF ID HGF2240 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17459026 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.69E-04). [7]
          rs17259859
             HGF ID HGF2263 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17259859 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.15E-05). [7]
          rs17104132
             HGF ID HGF2261 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17104132 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.15E-05). [7]
          rs17103802
             HGF ID HGF2262 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs17103802 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.06E-05). [7]
          rs16894459
             HGF ID HGF1400 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs16894459 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.85E-04). [7]
          rs16865867
             HGF ID HGF1379 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs16865867 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.19E-03). [7]
          rs16865853
             HGF ID HGF1380 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs16865853 SNP was significantly associated with the abundance of Desulfovibrio (p-value=8.36E-04). [7]
          rs16856759
             HGF ID HGF1541 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs16856759 SNP was significantly associated with the abundance of Desulfovibrio (p-value=6.63E-05). [7]
          rs1565122
             HGF ID HGF1643 HGF Info       Class Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
             Description The rs1565122 SNP was significantly associated with the abundance of Desulfovibrio (p-value=6.63E-04). [7]
          rs1529404
             HGF ID HGF2134 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1529404 SNP was significantly associated with the abundance of Desulfovibrio (p-value=4.32E-04). [7]
          rs1507705
             HGF ID HGF1814 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1507705 SNP was significantly associated with the abundance of Desulfovibrio (p-value=9.09E-04). [7]
          rs1386638
             HGF ID HGF1644 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1386638 SNP was significantly associated with the abundance of Desulfovibrio (p-value=7.04E-04). [7]
          rs13249293
             HGF ID HGF1975 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs13249293 SNP was significantly associated with the relative abundance of Desulfovibrio (p-value=9.19E-10). [8]
          rs12457158
             HGF ID HGF2166 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs12457158 SNP was significantly associated with the relative abundance of Desulfovibrio (p-value=2.53E-09). [8]
          rs12240997
             HGF ID HGF2260 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs12240997 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.23E-05). [7]
          rs1160133
             HGF ID HGF1978 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1160133 SNP was significantly associated with the abundance of Desulfovibrio (p-value=3.08E-05). [7]
          rs11047591
             HGF ID HGF2235 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs11047591 SNP was significantly associated with the abundance of Desulfovibrio (p-value=3.86E-04). [7]
          rs10842398
             HGF ID HGF2236 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10842398 SNP was significantly associated with the abundance of Desulfovibrio (p-value=5.03E-04). [7]
          rs10842120
             HGF ID HGF2241 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10842120 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.69E-04). [7]
          rs10770976
             HGF ID HGF2238 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10770976 SNP was significantly associated with the abundance of Desulfovibrio (p-value=1.69E-04). [7]
          rs10511591
             HGF ID HGF1476 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10511591 SNP was significantly associated with the abundance of Desulfovibrio (p-value=5.56E-06). [7]
          rs10173922
             HGF ID HGF1618 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10173922 SNP was significantly associated with the abundance of Desulfovibrio (p-value=6.91E-04). [7]
Host Immune Factors (HIFs)
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description the abundance of Desulfovibrio is associated with increased levels of IL-1beta in ulcerative colitis patients. [9]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Desulfovibrio is associated with increased levels of IL-6 in ulcerative colitis patients. [9]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Desulfovibrio was associated with the level of TNF-alpha. [9]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description T-cells were required to prevent expansion of Desulfovibrio. [10]
Environmental Factor(s)
             Disbiome ID
      2
             gutMDisorder ID
      gm0256
References
1 Gastrointestinal microbiota in children with autism in Slovakia. Physiol Behav. 2015 Jan;138:179-87. doi: 10.1016/j.physbeh.2014.10.033. Epub 2014 Nov 6.
2 Intestinal microbiota, chronic inflammation, and colorectal cancer. Intest Res. 2018 Jul;16(3):338-345. doi: 10.5217/ir.2018.16.3.338. Epub 2018 Jul 27.
3 Vasopressin deletion is associated with sex-specific shifts in the gut microbiome.Gut Microbes. 2018 Jan 2;9(1):13-25. doi: 10.1080/19490976.2017.1356557. Epub 2017 Aug 11.
4 The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice.Int J Mol Sci. 2018 Sep 18;19(9):2809. doi: 10.3390/ijms19092809.
5 Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.NPJ Biofilms Microbiomes. 2020 Jul 21;6(1):27. doi: 10.1038/s41522-020-0137-y.
6 Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2.Microbiome. 2019 Aug 22;7(1):116. doi: 10.1186/s40168-019-0733-3.
7 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
8 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
9 Anti-inflammatory properties and gut microbiota modulation of an alkali-soluble polysaccharide from purple sweet potato in DSS-induced colitis mice. Int J Biol Macromol. 2020 Jun 15;153:708-722. doi: 10.1016/j.ijbiomac.2020.03.053. Epub 2020 Mar 10.
10 T cell-mediated regulation of the microbiota protects against obesity.Science. 2019 Jul 26;365(6451):eaat9351. doi: 10.1126/science.aat9351.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.