Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01109)
MIC Name Rickettsia rickettsii (alpha-proteobacteria)
MIC Synonyms Dermacentroxenus rickettsii
Body Site Blood
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Rickettsiales
Family: Rickettsiaceae
Genus: Rickettsia
Species: Rickettsia rickettsii
Oxygen Sensitivity Aerobe
Microbial Metabolism Oxidative
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 1268188
Description Rickettsia rickettsii is a small, Gram negative, rod-shaped bacterium. It undergoes aerobic oxidation, and lives in a host-associated habitat. Rocky Mountain spotted fever (RMSF) is a bacterial disease caused by Rickettsia rickettsii, a bacterial pathogen transmitted to humans through contact with ticks.
External Links Taxonomy ID
783
Genome Assembly ID
ASM1744v3
GOLD Organism ID
Go0364557
Disease Relevance
          Spotted fever  [ICD-11: 1C31]
             Description Rickettsia rickettsii can cause Rocky Mountain spotted fever (RMSF). [1]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description The polypeptides, especially GWP, could induce a Th1-type immune response against Rickettsia rickettsii infection and stimulated CD4+ T cells from infected mice secreted significantly higher levels of IL-10. [2]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Rickettsia rickettsii is associated with IL-6 expression. [2]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Significantly higher levels of IFN-gamma or TNF-alpha secreted by CD4+ T cells from Rickettsia rickettsii-infected mice were detected after immunization with GWP. [2]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Significantly higher levels of IFN-gamma or TNF-alpha secreted by CD4+ T cells from Rickettsia rickettsii-infected mice were detected after immunization with GWP. [2]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description CD4+ T cells secreted significantly higher levels of IFN-gamma or TNF-alpha during Rickettsia rickettsii infection. [2]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Th1 epitope peptides can induce protective immunity against Rickettsia rickettsii infection. [2]
References
1 Rocky Mountain spotted fever in Mexico: past, present, and future. Lancet Infect Dis. 2017 Jun;17(6):e189-e196. doi: 10.1016/S1473-3099(17)30173-1. Epub 2017 Mar 30.
2 Th1 epitope peptides induce protective immunity against Rickettsia rickettsii infection in C3H/HeN mice. Vaccine. 2017 Dec 18;35(51):7204-7212. doi: 10.1016/j.vaccine.2017.09.068. Epub 2017 Oct 10.

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