General Information of MIC (ID: MIC00376)
MIC Name	Clostridiaceae (firmicutes)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Clostridiaceae
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Saccharolytic; Respiratory or Fermentative
Gram	Positive
Host Relationship	Probiotic
Description	The Clostridiaceae is a family of the bacterial class Clostridia, and contains the genus Clostridium.
External Links	Taxonomy ID	31979
Disease Relevance
Tuberculosis  [ICD-11: 1B10]
Description	Clostridiaceae was associated with tuberculosis.				[1]

Host Genetic Factors (HGFs)
ARNTL
HGF ID	HGF2325	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of BMAL1 could increase relative abundances of Clostridiaceae spp. (p-value<0.05).				[2]
TLR5
HGF ID	HGF2330	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of TLR5 could significantly decrease relative abundances of Clostridiaceae (p-value<0.05).				[3]
rs55828357
HGF ID	HGF2160	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs55828357 SNP was significantly associated with the abundance of Clostridiaceae bacterium (p-value<1.00E-08).				[4]
rs2076756
HGF ID	HGF1457	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The variant gene NOD2 of innate immunity rs2076756 is significantly associated with the abundance of gut micriobiota Clostridiaceae (p-value=0.0072).				[5]

Host Immune Factors (HIFs)
Interferon-6
HIF ID	HIFM0151	HIF Info	Class	Cytokine (Cyt)
Description	Clostridiaceae is associated with IL-6 expression.				[6]

Environmental Factor(s)
Disbiome ID			454
gutMDisorder ID			gm0182

References
1	Correlation between Disease Severity and the Intestinal Microbiome in Mycobacterium tuberculosis-Infected Rhesus Macaques. mBio. 2019 Jun 4;10(3):e01018-19. doi: 10.1128/mBio.01018-19.
2	Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock.Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10479-84. doi: 10.1073/pnas.1501305112. Epub 2015 Aug 3.
3	Deletion of the Toll-Like Receptor 5 Gene Per Se Does Not Determine the Gut Microbiome Profile That Induces Metabolic Syndrome: Environment Trumps Genotype.PLoS One. 2016 Mar 7;11(3):e0150943. doi: 10.1371/journal.pone.0150943. eCollection 2016.
4	Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
5	Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
6	Impact of probiotic Saccharomyces boulardii on the gut microbiome composition in HIV-treated patients: A double-blind, randomised, placebo-controlled trial. PLoS One. 2017 Apr 7;12(4):e0173802. doi: 10.1371/journal.pone.0173802. eCollection 2017.

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