Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00967)
MIC Name Pasteurella multocida (gamma-proteobacteria)
MIC Synonyms Bacterium multocidum
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pasteurellales
Family: Pasteurellaceae
Genus: Pasteurella
Species: Pasteurella multocida
Oxygen Sensitivity Facultative anaerobe; Aerobe
Microbial Metabolism Energy metabolism
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 2271840
No. of Coding Genes 2064
No. of Non-Coding Genes 61
No. of Small Non-Coding Genes 61
No. of Gene Transcripts 2125
No. of Base Pairs 2303803
Description Pasteurella multocida is a aerobic to facultatively anaerobic, Gram-negative, non-motile, non-sporulating, coccobacillus bacterium found in the oral flora of many animals and the frequent cause of local infection after bite injuries.
External Links Taxonomy ID
747
Genome Assembly ID
ASM73173v1
GOLD Organism ID
Go0005634
Disease Relevance
          Chronic obstructive pulmonary disease  [ICD-11: CA22]
             Description Pasteurella multocida was associated with bovine respiratory disease complex. [1]
          Sepsis  [ICD-11: 1G40]
             Description Pasteurella multocida was associated with haemorrhagic septicaemia. [2]
Host Immune Factors (HIFs)
          Interferon-12 subunit alpha
             HIF ID HIFM0130 HIF Info       Class Cytokine (Cyt)
             Description Pasteurella multocida LPS was also able to induce the expression and the subsequent release of proinflammatory and immunomodulatory cytokines such as IL-12 from a mix of murine splenocytes. [3]
          Interleukin-1 alpha
             HIF ID HIFM0137 HIF Info       Class Cytokine (Cyt)
             Description Pasteurella multocida was able to induce the subsequent immunomodulatory cytokines such as IL-1alpha. [3]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Pasteurella multocida was able to induce the subsequent immunomodulatory cytokines such as IL-6. [3]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Pasteurella multocida LPS could induce the expression and the subsequent release of proinflammatory and immunomodulatory cytokines such as IL-1a, IL-6, TNF-alpha, IFN-gamma and IL-12 from a mix of murine splenocytes. [3]
          Type I group 2 IFN-c1
             HIF ID HIFM0261 HIF Info       Class Cytokine (Cyt)
             Description Pasteurella multocida LPS could induce the expression and the subsequent release of proinflammatory and immunomodulatory cytokines such as IL-1a, IL-6, TNF-alpha, IFN-gamma and IL-12 from a mix of murine splenocytes. [3]
          Toll like receptor 4 signaling pathway
             HIF ID HIFP0046 HIF Info       Class Signaling pathway (SP)
             Description Pasteurella multocida LPS could induce the expression and the subsequent release of proinflammatory and immunomodulatory cytokines such as IL-1a, IL-6, TNF-alpha, IFN-gamma and IL-12 from a mix of murine splenocytes. [3]
Environmental Factor(s)
             Disbiome ID
      820
References
1 Mutual antagonism between Mannheimia haemolytica and Pasteurella multocida when forming a biofilm on bovine bronchial epithelial cells in vitro. Vet Microbiol. 2018 Mar;216:218-222. doi: 10.1016/j.vetmic.2018.02.015. Epub 2018 Feb 12.
2 Molecular study on Pasteurella multocida and Mannheimia granulomatis from Kenyan Camels (Camelus dromedarius). BMC Vet Res. 2017 Aug 22;13(1):265. doi: 10.1186/s12917-017-1189-y.
3 Pasteurella multocida and immune cells. Curr Top Microbiol Immunol. 2012;361:53-72. doi: 10.1007/82_2012_204.

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