General Information of HIF (ID: HIFM0261)
HIF Name	Type I group 2 IFN-c1
HIF Synonym(s)	LOC115170661
HIF Classification	Cytokine (Cyt)
Description	Since IFN-c is produced by donor T cells in response to antigen recognition, we tested whether it could initiate MSC efficacy in vivo and observed a dose-response effect, with higher doses of IFN-c being more effective than lower				[1]

Microbe Species (MIC) Regulated by This HIF
Pasteurella multocida (gamma-proteobacteria)			MIC00967
Description	Pasteurella multocida LPS could induce the expression and the subsequent release of proinflammatory and immunomodulatory cytokines such as IL-1a, IL-6, TNF-alpha, IFN-gamma and IL-12 from a mix of murine splenocytes.				[2]
Pediococcus pentosaceus (firmicutes)			MIC01430
Description	Exopolysaccharide fractions from Pediococcus pentosaceus stimulated IFN-c-primed macrophages and primary splenocytes to induce immune responses.				[3]

References
1	NK-cells are involved in thymic atrophy induced by influenza A virus infection.J Gen Virol. 2015 Nov;96(11):3223-3235. doi: 10.1099/jgv.0.000276.
2	Pasteurella multocida and immune cells. Curr Top Microbiol Immunol. 2012;361:53-72. doi: 10.1007/82_2012_204.
3	Comparative Genomics of Pediococcus pentosaceus Isolated From Different Niches Reveals Genetic Diversity in Carbohydrate Metabolism and Immune System. Front Microbiol. 2020 Feb 26;11:253. doi: 10.3389/fmicb.2020.00253. eCollection 2020.

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