Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00280)
MIC Name Burkholderia cenocepacia (beta-proteobacteria)
MIC Synonyms Burkholderia cepacia genomovar III
Body Site Lung
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Burkholderia
Species: Burkholderia cenocepacia
Oxygen Sensitivity Aerobe
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 8055782
No. of Coding Genes 6967
No. of Non-Coding Genes 69
No. of Small Non-Coding Genes 69
No. of Gene Transcripts 7036
No. of Base Pairs 7979184
Description Burkholderia cenocepacia is a Gram-negative aerobic bacterium that belongs to a group of opportunistic pathogens displaying diverse environmental and pathogenic lifestyles. Burkholderia cenocepacia is an opportunistic pathogen that has a propensity to infect cystic fibrosis patients.
External Links Taxonomy ID
95486
Genome Assembly ID
BukCp6.0
GOLD Organism ID
Go0520774
Disease Relevance
          Cystic fibrosis  [ICD-11: CA25]
             Description Burkholderia cenocepacia, a bacterium commonly found in the environment, is an important opportunistic pathogen in patients with cystic fibrosis (CF). [1]
Host Immune Factors (HIFs)
          Interferon-12 subunit alpha
             HIF ID HIFM0130 HIF Info       Class Cytokine (Cyt)
             Description Burkholderia cenocepacia could increase the expression of IL-12. [2]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Dendritic cells infected with Burkholderia cenocepacia have an increased expression of IL-1beta mRNA level. [2]
          Interleukin-23 subunit alpha
             HIF ID HIFM0144 HIF Info       Class Cytokine (Cyt)
             Description Burkholderia cenocepacia induced high expression of inflammatory cytokines IL-23. [2]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Burkholderia cenocepacia could increase the expression of IL-6. [2]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description The expression of IL-8 upregulated in alveolar epithelial cells after infection Burkholderia cenocepacia. [2]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Burkholderia cenocepacia could increase the expression of TNF-Alpha. [2]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description All Burkholderia cenocepacia-infected dendritic cells(DCs) failed to upregulate maturation markers, HLA-DR, CD80, CD86 and CD83. [2]
Environmental Factor(s)
             Disbiome ID
      371
             gutMDisorder ID
      gm0131
             aBiofilm Organism
      Burkholderia cenocepacia
References
1 The mgtC gene of Burkholderia cenocepacia is required for growth under magnesium limitation conditions and intracellular survival in macrophages. Infect Immun. 2006 Oct;74(10):5477-86. doi: 10.1128/IAI.00798-06.
2 Using dendritic cells to evaluate how Burkholderia cenocepacia clonal isolates from a chronically infected cystic fibrosis patient subvert immune functions. Med Microbiol Immunol. 2017 Apr;206(2):111-123. doi: 10.1007/s00430-016-0488-4. Epub 2016 Dec 16.

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