Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00762)
MIC Name Leptotrichia goodfellowii (fusobacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Leptotrichiaceae
Genus: Leptotrichia
Species: Leptotrichia goodfellowii
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic
Gram Negative
Host Relationship Pathogen
Description Leptotrichia goodfellowii is an anaerobic, Gram negative, non-spore-forming and non-motile bacterium from the genus of Leptotrichia which has been isolated from human blood of an endocarditis patient.
External Links Taxonomy ID
157692
Genome Assembly ID
ASM17633v1
GOLD Organism ID
Go0200365
Disease Relevance
          Infectious endocarditis  [ICD-11: BB40]
             Description Leptotrichia goodfellowii was associated with endocardial infection. [1]
Host Genetic Factors (HGFs)
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Oral microbiome Leptotrichia differs between high AMY1-CN and low AMY1-CN groups at the OTU level (p-value<0.05). [2]
          rs6507870
             HGF ID HGF1627 HGF Info       Class Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
             Description The rs6507870 SNP was significantly associated with the abundance of Leptotrichia goodfellowii (p-value<1.00E-08). [3]
          rs2458105
             HGF ID HGF1859 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2458105 SNP was significantly associated with the abundance of Leptotrichia goodfellowii (p-value<1.00E-08). [3]
          rs690367
             HGF ID HGF1259 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs690367 SNP was significantly associated with the abundance of Leptotrichia (p-value=6.95E-06). [4]
          rs3809482
             HGF ID HGF1249 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs3809482 SNP was significantly associated with the abundance of Leptotrichia (p-value=1.04E-06). [4]
          rs2278857
             HGF ID HGF1949 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs2278857 SNP was significantly associated with the abundance of Leptotrichia (p-value=8.67E-06). [4]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Leptotrichia could trigger the transcription expression level of IL-10. [5]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Leptotrichia was able to trigger the transcription level of proinflammatory interleukin (IL)-1 in epithelial cell. [5]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Leptotrichia could trigger the transcription expression level of IL-6. [5]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Leptotrichia could trigger the transcription expression level of IL-8. [5]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Leptotrichia can interact with dendritic cells response. [5]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Leptotrichia was able to trigger the transcription level of IL-10 in epithelial cells which could prohibit excessive immune response by suppressing the antigen-presenting capacity of macrophages. [5]
          Monocytes
             HIF ID HIFC0024 HIF Info       Class Monocytes (Mono)
             Description Leptotrichia was able to trigger the transcription level of IL-10 in epithelial cells which could prohibit excessive immune response by suppressing the antigen-presenting capacity of monocytes. [5]
Environmental Factor(s)
             Disbiome ID
      1373
             gutMDisorder ID
      gm0422
References
1 Subacute Bacterial Endocarditis with Leptotrichia goodfellowii in a Patient with a Valvular Allograft: A Case Report and Review of the Literature. Case Rep Infect Dis. 2016;2016:3051212. doi: 10.1155/2016/3051212. Epub 2016 Nov 8.
2 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
3 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
4 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
5 Leptotrichia species in human infections II. J Oral Microbiol. 2017 Sep 15;9(1):1368848. doi: 10.1080/20002297.2017.1368848. eCollection 2017.

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