Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01335)
MIC Name Trueperella pyogenes (actinobacteria)
MIC Synonyms Bacillus pyogenes
Body Site Mucosa
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Actinomycetales
Family: Actinomycetaceae
Genus: Trueperella
Species: Trueperella pyogenes
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Opportunistic pathogen
Genome Size (bp) 2295822
No. of Coding Genes 1984
No. of Non-Coding Genes 53
No. of Small Non-Coding Genes 53
No. of Gene Transcripts 2037
No. of Base Pairs 2338390
Description Trueperella pyogenes is a facultatively anaerobic,Gram-positive,nonmotile,pleomorphic or coccoid rods bacteria.The bacterium tends to be grouped singly, or in short chains. Sometimes, they are grouped into V-shaped pairs. It is most commonly incriminated as a cause of abscesses, wound infections, pneumonia, arthritis, mastitis, foot infections, osteomyelitis of vertebral bodies, pituitary abscessation, abortion, perinatal mortalities.
External Links Taxonomy ID
1661
Genome Assembly ID
ASM61205v1
GOLD Organism ID
Go0087736
Disease Relevance
          Intracranial abscess  [ICD-11: 1D03]
             Description Trueperella pyogenes was a causative agent of cranial abscess disease. [1]
Host Immune Factors (HIFs)
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Trueperella pyogenes is associated with IL-1beta expression. [2]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Trueperella pyogenes is associated with IL-6 expression. [2]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Trueperella pyogenes is associated with IL-8 expression. [2]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Trueperella pyogenes is associated with TNF-Alpha. [2]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Trueperella pyogenes is associated with macrophages response. [2]
Environmental Factor(s)
             aBiofilm Organism
      Trueperella pyogenes
References
1 Isolation and genotypic characterization of Trueperella (Arcanobacterium) pyogenes recovered from active cranial abscess infections of male white-tailed deer (Odocoileus virginianus). J Zoo Wildl Med. 2015 Mar;46(1):62-7. doi: 10.1638/2014-0124R1.1.
2 Quorum-sensing molecules N-acyl homoserine lactones inhibit Trueperella pyogenes infection in mouse model. Vet Microbiol. 2018 Jan;213:89-94. doi: 10.1016/j.vetmic.2017.11.029. Epub 2017 Nov 22.

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