Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01274)
MIC Name Streptococcus uberis (firmicutes)
Body Site Skin
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus uberis
Oxygen Sensitivity Aerobe
Microbial Metabolism Saccharolytic; Respiratory
Gram Positive
Host Relationship Pathogen
Genome Size (bp) 1852352
No. of Coding Genes 1646
No. of Non-Coding Genes 49
No. of Small Non-Coding Genes 49
No. of Gene Transcripts 1692
No. of Base Pairs 2149440
Description Streptococcus uberis is a species of aerobic, Gram positive bacterium of Streptococcus. It is the most common Streptococcus species isolated from cases of mastitis.
External Links Taxonomy ID
1349
Genome Assembly ID
CAIM1894t_spades_scaffold
GOLD Organism ID
Go0468631
Disease Relevance
          Inflammatory disorders of breast  [ICD-11: GB21]
             Description Streptococcus uberis was associated with mastitis. [1]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus uberis infection could up-regulated IL-10 expression. [2]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description The majority of genes with 1.5-fold change within IL-6 Signaling were up-regulated due to inoculated with the 5,000 cfu of Streptococcus uberis intramammary infection. [2]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description The milk concentrations of IL-8 was elevated after challenged with Streptococcus uberis. [2]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description The gene of TNF could regulate (44.9 fold) after IMI challenge with Streptococcus uberis. [2]
          Interleukin 10 signaling pathway
             HIF ID HIFP0012 HIF Info       Class Signaling pathway (SP)
             Description Streptococcus uberis intramammary infection could active IL-10 Signaling pathway and IL-6 Signaling pathway. [2]
          Interleukin 6 signaling pathway
             HIF ID HIFP0015 HIF Info       Class Signaling pathway (SP)
             Description Streptococcus uberis intramammary infection could active IL-10 Signaling pathway and IL-6 Signaling pathway. [2]
          Liver X receptor signaling pathway
             HIF ID HIFP0022 HIF Info       Class Signaling pathway (SP)
             Description Streptococcus uberis intramammary infection could inhibite LXR/RXR Signaling pathway. [2]
          Retinoid X receptor signaling pathway
             HIF ID HIFP0036 HIF Info       Class Signaling pathway (SP)
             Description Streptococcus uberis intramammary infection could inhibite LXR/RXR Signaling pathway. [2]
Environmental Factor(s)
             Disbiome ID
      62
             gutMDisorder ID
      gm0624
References
1 Correlation of hypothetical virulence traits of two Streptococcus uberis strains with the clinical manifestation of bovine mastitis. Vet Res. 2015 Oct 23;46:123. doi: 10.1186/s13567-015-0268-y.
2 Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and lipid metabolism. BMC Genomics. 2009 Nov 19;10:542. doi: 10.1186/1471-2164-10-542.

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