General Information of HIF (ID: HIFP0015)
HIF Name	Interleukin 6 signaling pathway
HIF Synonym(s)	IL-6 Signaling, IL-6 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	Activation of gp130 via the IL-6/sIL-6R complex is termed IL-6 trans-signaling pathway, whereas activation of gp130 via the mbIL-6R is named IL-6 classic signaling pathway				[1]

Microbe Species (MIC) Regulated by This HIF
Streptococcus uberis (firmicutes)			MIC01274
Description	Streptococcus uberis intramammary infection could active IL-10 Signaling pathway and IL-6 Signaling pathway.				[2]

References
1	IL-6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma.J Cell Biochem. 2018 Nov;119(11):9419-9432. doi: 10.1002/jcb.27259. Epub 2018 Jul 17.
2	Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and lipid metabolism. BMC Genomics. 2009 Nov 19;10:542. doi: 10.1186/1471-2164-10-542.

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