General Information of HIF (ID: HIFP0022)
HIF Name	Liver X receptor signaling pathway
HIF Synonym(s)	LXR Signaling, LXR signaling pathway
HIF Classification	Signaling pathway (SP)
Description	Mechanistically, the anti-inflammatory effects of LXR have been attributed to nuclear inhibition of NF-kB signaling via a process known as transrepression. 20 Subsequent studies demonstrated that LXR also attenuates expression of the NF-kB target gene MMP-9 both in vivo and in vitro.				[1]

Microbe Species (MIC) Regulated by This HIF
Streptococcus uberis (firmicutes)			MIC01274
Description	Streptococcus uberis intramammary infection could inhibite LXR/RXR Signaling pathway.				[2]

References
1	Liver x receptor signaling pathways and atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1513-8. doi: 10.1161/ATVBAHA.109.191197.
2	Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and lipid metabolism. BMC Genomics. 2009 Nov 19;10:542. doi: 10.1186/1471-2164-10-542.

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