General Information of HIF (ID: HIFP0036)
HIF Name	Retinoid X receptor signaling pathway
HIF Synonym(s)	RXR Signaling, RXR signaling pathway
HIF Classification	Signaling pathway (SP)
Description	RAR/RXR signaling has major regulatory functions in inflammation and the immune system. A third area where the role of RA is becoming evident is the physiology of the nervous system, specifically the regulation of synaptic plasticity and axonal regeneration				[1]

Microbe Species (MIC) Regulated by This HIF
Streptococcus uberis (firmicutes)			MIC01274
Description	Streptococcus uberis intramammary infection could inhibite LXR/RXR Signaling pathway.				[2]

References
1	Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity.Mol Brain. 2012 Feb 8;5:8. doi: 10.1186/1756-6606-5-8.
2	Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and lipid metabolism. BMC Genomics. 2009 Nov 19;10:542. doi: 10.1186/1471-2164-10-542.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.