Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0012)
HIF Name	Interleukin 10 signaling pathway
HIF Synonym(s)	IL-10 Signaling, IL-10 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	IL-10 signaling pathway Interleukin-10 ( IL-10 ) is a pleiotropic cytokine with important immunoregulatory functions.	[1]

Microbe Species (MIC) Regulated by This HIF
Streptococcus uberis (firmicutes)		MIC01274
Description	Streptococcus uberis intramammary infection could active IL-10 Signaling pathway and IL-6 Signaling pathway.		[2]

References
1	The molecular basis of IL-10 function: from receptor structure to the onset of signaling.Curr Top Microbiol Immunol. 2014;380:191-212. doi: 10.1007/978-3-662-43492-5_9.
2	Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and lipid metabolism. BMC Genomics. 2009 Nov 19;10:542. doi: 10.1186/1471-2164-10-542.

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