Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00525)
MIC Name Eikenella corrodens (beta-proteobacteria)
MIC Synonyms Ristella corrodens
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Neisseriales
Family: Neisseriaceae
Genus: Eikenella
Species: Eikenella corrodens
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Nonfermentative
Gram Negative
Genome Size (bp) 2135355
No. of Coding Genes 2125
No. of Non-Coding Genes 52
No. of Small Non-Coding Genes 52
No. of Gene Transcripts 2196
No. of Pseudogenes 19
No. of Base Pairs 2203048
Description Eikenella corrodens is a species of facultative anaerobic, Gram negative, non-motile, non-sporeforming pathogenic bacillus that exists in the form of a straight rod. This bacterium is an opportunistic human pathogen. Eikenella corrodens infection may lead to serious diseases such as periodontitis, osteomyelitis, meningitis, empyema, and endocarditis.
External Links Taxonomy ID
539
Genome Assembly ID
ASM164823v1
GOLD Organism ID
Go0003877
Disease Relevance
          Appendicitis  [ICD-11: DB10]
             Description Viable amounts of Eikenella corrodens was decreased compared to sulci of children with appendicitis. [1]
          Bacterial meningitis  [ICD-11: 1D01]
             Description Eikenella corrodens can cause meningitis. [2]
          Empyema  [ICD-11: CA44]
             Description Eikenella corrodens: an unusual cause of severe parapneumonic infection and empyema in immunocompetent patients. [3]
          Infectious endocarditis  [ICD-11: BB40]
             Description Eikenella corrodens is a gram-negative bacterium, and although primarily associated with periodontal infections or infective endocarditis. [4]
          Osteomyelitis or osteitis  [ICD-11: FB84]
             Description Eikenella corrodens was associated with osteomyelitis. [5]
          Periodontal disease  [ICD-11: DA0C]
             Description A limited number of clones of Eikenella corrodens may be associated with periodontal disease and/or extraoral infection.Additional studies, possibly employing strain-specific nucleic acid probes, may be required to define the role of Eikenella corrodens as a human periodontal. [6]
Host Genetic Factors (HGFs)
          rs12955474
             HGF ID HGF1881 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12955474 SNP was significantly associated with the abundance of Eikenella corrodens (p-value<1.00E-08). [7]
          rs56241474
             HGF ID HGF1855 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs56241474 SNP was associated with the abundance of Eikenella (p-value=7.33E-07). [8]
Host Immune Factors (HIFs)
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description A slight stimulation of the IL-6 mRNA levels was seen when Eikenella corrodens was separated from KB cells by cell culture inserts. [9]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description A slight stimulation of the IL-8 mRNA levels was seen when Eikenella corrodens was separated from KB cells by cell culture inserts. [9]
Environmental Factor(s)
             Disbiome ID
      364
             gutMDisorder ID
      gm0273
             aBiofilm Organism
      Eikenella corrodens
References
1 The oral microbiome-the relevant reservoir for acute pediatric appendicitis. Int J Colorectal Dis. 2018 Feb;33(2):209-218. doi: 10.1007/s00384-017-2948-8. Epub 2017 Dec 22.
2 Chronic meningitis caused by Eikenella corrodens. Kaohsiung J Med Sci. 2013 Aug;29(8):466-7. doi: 10.1016/j.kjms.2012.12.009. Epub 2013 Mar 5.
3 Eikenella corrodens: an unusual cause of severe parapneumonic infection and empyema in immunocompetent patients. J Natl Med Assoc. 2001 Jun;93(6):224-9.
4 Eikenella corrodens lipopolysaccharide stimulates the pro-atherosclerotic response in human coronary artery endothelial cells and monocyte adhesion. Eur J Oral Sci. 2018 Dec;126(6):476-484. doi: 10.1111/eos.12580. Epub 2018 Oct 24.
5 Eikenella corrodens osteomyelitis, arthritis, and cellulitis of the hand. South Med J. 1976 May;69(5):535-9, 549. doi: 10.1097/00007611-197605000-00018.
6 Eikenella corrodens in human oral and non-oral infections: a review. J Periodontol. 1992 Dec;63(12):941-53. doi: 10.1902/jop.1992.63.12.941.
7 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
8 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
9 Interleukin-6 (IL-6) and IL-8 are induced in human oral epithelial cells in response to exposure to periodontopathic Eikenella corrodens. Infect Immun. 1999 Jan;67(1):384-94.

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