Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01251)
MIC Name Streptococcus gallolyticus (firmicutes)
MIC Synonyms Streptococcus caprinus
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus gallolyticus
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Pathogen
Genome Size (bp) 2639074
No. of Coding Genes 1934
No. of Non-Coding Genes 69
No. of Small Non-Coding Genes 69
No. of Gene Transcripts 2409
No. of Pseudogenes 406
No. of Base Pairs 2639074
Description The opportunistic pathogen Streptococcus gallolyticus subsp. gallolyticus (Sgg) is asymptomatically found in the gastrointestinal tract of humans (2.5 15%), ruminants and birds.
External Links Taxonomy ID
315405
Genome Assembly ID
SGAL
GOLD Organism ID
Go0011182
Disease Relevance
          Colon cancer  [ICD-11: 2B90]
             Description Colon carcinoma was associated with Streptococcus bovis infection. [1]
          Colorectal cancer  [ICD-11: 2B91]
             Description Streptococcus gallolyticus was associated with colorectal cancer. [2]
          Infectious endocarditis  [ICD-11: BB40]
             Description Streptococcus gallolyticus can cause the coincidence of infective endocarditis (IE). [3]
          Meningococcal disease  [ICD-11: 1C1C]
             Description Streptococcus gallolyticus was associated with bacteraemia. [4]
          Urinary tract infection  [ICD-11: GC08]
             Description Streptococcus gallolyticus may cause urinary tract infection. [5]
Host Immune Factors (HIFs)
          C-C motif chemokine 2
             HIF ID HIFM0022 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus gallolyticus could increase the CCL2 expression. [6]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description IL-1b is more highly expressed in adenocarcinoma from mice that were introduced with Streptococcus gallolyticus. [6]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus gallolyticus infection could increase expression of IL-6. [6]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus gallolyticus could increase the expression of IL-8. [6]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus gallolyticus could increase TNF-Alpha. [6]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Streptococcus gallolyticus selectively recruits tumor-infiltrating myeloid cells but not mast cells, including dendritic cells. [6]
          Immunoglobulin G2
             HIF ID HIFM0268 HIF Info       Class Immunoglobulin (Ig)
             Description Prediagnosis IgG2 titers could be against the Streptococcus gallolyticus strain. [7]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description Prediagnosis IgG2 titers could be against the Streptococcus gallolyticus strain. [7]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Streptococcus gallolyticus selectively recruits tumor-infiltrating myeloid cells but not mast cells, including tumor-associated macrophages. [6]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Streptococcus gallolyticus selectively recruits tumor-infiltrating myeloid cells which can inhibit competence of T cells. [6]
Environmental Factor(s)
             Disbiome ID
      727
             gutMDisorder ID
      gm0624
References
1 [Diseases associated with bloodstream infections caused by the new species included in the old Streptococcus bovis group]. Enferm Infecc Microbiol Clin. 2012 Apr;30(4):175-9. doi: 10.1016/j.eimc.2011.09.015. Epub 2012 Feb 28.
2 The Role of the Gut Microbiota in Colorectal Cancer Causation. Int J Mol Sci. 2019 Oct 24;20(21):5295. doi: 10.3390/ijms20215295.
3 Beneficial bacteria activate type-I interferon production via the intracellular cytosolic sensors STING and MAVS. Gut Microbes. 2020 Jul 3;11(4):771-788. doi: 10.1080/19490976.2019.1707015. Epub 2020 Jan 15.
4 Association Between Bacteremia From Specific Microbes and Subsequent Diagnosis of Colorectal Cancer. Gastroenterology. 2018 Aug;155(2):383-390.e8. doi: 10.1053/j.gastro.2018.04.028. Epub 2018 May 3.
5 Early onset neonatal bacterial meningitis caused by Streptococcus gallolyticus subsp. paste urianus. Southeast Asian J Trop Med Public Health. 2012 Jan;43(1):145-51.
6 Streptococcus gallolyticus conspires myeloid cells to promote tumorigenesis of inflammatory bowel disease. Biochem Biophys Res Commun. 2018 Dec 2;506(4):907-911. doi: 10.1016/j.bbrc.2018.10.136. Epub 2018 Nov 2.
7 Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children.Sci Immunol. 2019 Feb 1;4(32):eaau8125. doi: 10.1126/sciimmunol.aau8125.

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