Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00963)
MIC Name Parasutterella excrementihominis (beta-proteobacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Sutterellaceae
Genus: Parasutterella
Species: Parasutterella excrementihominis
Oxygen Sensitivity Strictly anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Genome Size (bp) 2831860
Description Parasutterella excrementihominis is a Gram-negative, strictly anaerobic, non-spore-forming bacterium of the genus Parasutterella in the family Sutterellaceae, isolated from human faeces.
External Links Taxonomy ID
487175
Genome Assembly ID
ASM20502v1
GOLD Organism ID
Go0006612
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Parasutterella excrementihominis was significantly elevated in autistic children. [1]
          Retinal artery occlusions  [ICD-11: 9B74]
             Description Parasutterella was associated with retinal artery occlusion. [2]
Host Genetic Factors (HGFs)
          15q11-13
             HGF ID HGF2318 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The duplicaton of 15q is assciated with the reduction of the relative abundance of Parasuterella caused by ampicillin (p-value<0.05). [3]
          rs2894049
             HGF ID HGF1497 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2894049 SNP was significantly associated with the abundance of Parasutterella excrementihominis (p-value<1.00E-08). [4]
Host Immune Factors (HIFs)
          HD-5(1-9)
             HIF ID HIFM0289 HIF Info       Class Antimicrobial peptide (AMP)
             Description HD-519 treatment could increase Parasutterella. [5]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Parasutterella is associated with increased levels of IL-1beta in ulcerative colitis patients. [6]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Parasutterella is associated with increased levels of IL-6 in ulcerative colitis patients. [6]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Parasutterella was associated with the level of TNF-alpha. [6]
Environmental Factor(s)
             Disbiome ID
      613
             gutMDisorder ID
      gm0502
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Retinal artery occlusion is associated with compositional and functional shifts in the gut microbiome and altered trimethylamine-N-oxide levels. Sci Rep. 2019 Oct 25;9(1):15303. doi: 10.1038/s41598-019-51698-5.
3 Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice.Neurosci Res. 2019 Dec 18:S0168-0102(19)30671-6. doi: 10.1016/j.neures.2019.12.010. Online ahead of print.
4 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
5 Paneth cell -defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments.Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3746-3751. doi: 10.1073/pnas.1817376116. Epub 2019 Feb 11.
6 Anti-inflammatory properties and gut microbiota modulation of an alkali-soluble polysaccharide from purple sweet potato in DSS-induced colitis mice. Int J Biol Macromol. 2020 Jun 15;153:708-722. doi: 10.1016/j.ijbiomac.2020.03.053. Epub 2020 Mar 10.

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