General Information of HIF (ID: HIFM0289)
HIF Name	HD-5(1-9)
HIF Synonym(s)	Hd-5(1-9)
HIF Classification	Antimicrobial peptide (AMP)
Description	HD-5(1-9) has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
External Links
	APD ID	AP03063

Microbe Species (MIC) Regulated by This HIF
Akkermansia sp. (verrucomicrobia)			MIC00057
Description	HD-519 treatment could significantly increase the Akkermansia sp..				[2]
Bacteroides sp. (CFB bacteria)			MIC00176
Description	HD-519 treatment could decrease the ralative abundance of the genera Bacteroides.				[2]
Lactobacillus sp. (firmicutes)			MIC00701
Description	HD-519 treatment could decrease Lactobacillus.				[2]
Parasutterella excrementihominis (beta-proteobacteria)			MIC00963
Description	HD-519 treatment could increase Parasutterella.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Paneth cell -defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments.Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3746-3751. doi: 10.1073/pnas.1817376116. Epub 2019 Feb 11.

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