Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00103)
MIC Name Aspergillus fumigatus (ascomycetes)
MIC Synonyms Aspergillus fumigates
Body Site Lung
Lineage Kingdom: Eukaryota
Phylum: Ascomycota
Class: Eurotiomycetes
Order: Eurotiales
Family: Aspergillaceae
Genus: Aspergillus
Species: Aspergillus fumigatus
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 29384958
Description Aspergillus fumigatus is a species of fungus in the genus Aspergillus. It can cause disease in individuals with an immunodeficiency.
External Links Taxonomy ID
746128
Genome Assembly ID
ASM576862v2
GOLD Organism ID
Go0039835
Disease Relevance
          Cystic fibrosis  [ICD-11: CA25]
             Description Aspergillus fumigatus was associated with cystic fibrosis. [1]
Host Genetic Factors (HGFs)
          hsa-miR-630
             HGF ID HGF0692 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miRNA miR-630 might exhibit critical roles in Aspergillus fumigatus-induced CD4+ T cell maturation and activation. [2]
          hsa-miR-574-5p
             HGF ID HGF0688 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miRNA miR-574-5p might exhibit critical roles in Aspergillus fumigatus-induced CD4+ T cell maturation and activation. [2]
          hsa-miR-494-5p
             HGF ID HGF0687 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miRNA miR-494 might exhibit critical roles in Aspergillus fumigatus-induced CD4+ T cell maturation and activation. [2]
          hsa-miR-142-3p
             HGF ID HGF0648 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The microRNA-142-3p inhibited IFN-gamma production via targeting of RICTOR in Aspergillus fumigatus activated CD4+ T cells. [2]
          hsa-miR-129-5p
             HGF ID HGF0272 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-129-5p could regulate target genes FKBP1B and BTN3A2 in response to Aspergillus fumigatus infection. [3]
          hsa-miR-130b-3p
             HGF ID HGF0269 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miRNA miR-130b-3p might exhibit critical roles in Aspergillus fumigatus-induced CD4+ T cell maturation and activation. [2]
          hsa-miR-132-3p
             HGF ID HGF0267 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-132-3p was significantly up-regulated in denditic cells in response to Aspergillus fumigatus stimulation (p-value<0.05). [4]
          hsa-miR-212-3p
             HGF ID HGF0201 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-212-3p was significantly down-regulated in brain-related disorder with Aspergillus fumigatus infection (p-value<0.05). [3]
          hsa-miR-23a-3p
             HGF ID HGF0192 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The pulmonary hsa-miR-23a-3p expression was altered by chronic Aspergillus fumigatus exposure. [5]
          hsa-miR-29a-3p
             HGF ID HGF0178 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-29a-3p was down-regulated significantly in innate responses to viable Aspergillus fumigatus (p-value<0.05). [5]
          hsa-miR-652-3p
             HGF ID HGF0096 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miRNA miR-652-3p might exhibit critical roles in Aspergillus fumigatus-induced CD4+ T cell maturation and activation. [2]
Host Immune Factors (HIFs)
          Human drosomycin-like defensin
             HIF ID HIFM0298 HIF Info       Class Antimicrobial peptide (AMP)
             Description Human drosomycin-like defensin exerted strong fungicidal effects against the important human pathogen Aspergillus fumigatus. [6]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Aspergillus fumigatus could reduce gene expression and secretion of IL-6. [7]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Dendritic cells (DCs) are critical for protection against pathogenic Aspergillus fumigatus. [7]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Macrophages are critical for protection against pathogenic Aspergillus fumigatus. [7]
          Monocytes
             HIF ID HIFC0024 HIF Info       Class Monocytes (Mono)
             Description Recruitment of monocytes is essential for effective control and clearance of Aspergillus fumigatus. [8]
Environmental Factor(s)
             Disbiome ID
      1351
             aBiofilm Organism
      Aspergillus fumigatus
References
1 Aspergillus fumigatus Preexposure Worsens Pathology and Improves Control of Mycobacterium abscessus Pulmonary Infection in Mice. Infect Immun. 2018 Feb 20;86(3):e00859-17. doi: 10.1128/IAI.00859-17. Print 2018 Mar.
2 MicroRNA-142-3p inhibits IFN- production via targeting of RICTOR in Aspergillus fumigatus activated CD4(+) T cells. Ann Transl Med. 2019 Nov;7(22):649. doi: 10.21037/atm.2019.10.85.
3 Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function. Roy S, Elgharably H, Sinha M, Ganesh K, Chaney S, Mann E, Miller C, Khanna S, Bergdall VK, Powell HM, Cook CH, Gordillo GM, Wozniak DJ, Sen CK.. J Pathol. 2014 Aug;233(4):331-343. doi: 10.1002/path.4360. Epub 2014 May 27.
4 Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells. Int J Med Microbiol. 2014 Jul;304(5-6):592-6. doi: 10.1016/j.ijmm.2014.04.005. Epub 2014 Apr 26.
5 miRNAs in precancerous lesions of the gastrointestinal tract. Fassan M, Croce CM, Rugge M.. World J Gastroenterol. 2011 Dec 28;17(48):5231-9. doi: 10.3748/wjg.v17.i48.5231.
6 Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity.Antimicrob Agents Chemother. 2008 Apr;52(4):1407-12. doi: 10.1128/AAC.00155-07. Epub 2008 Jan 22.
7 Influence of Platelet-rich Plasma on the immune response of human monocyte-derived dendritic cells and macrophages stimulated with Aspergillus fumigatus. Int J Med Microbiol. 2017 Feb;307(2):95-107. doi: 10.1016/j.ijmm.2016.11.010. Epub 2016 Dec 9.
8 Monocyte recruitment during infection and inflammation.Nat Rev Immunol. 2011 Oct 10;11(11):762-74. doi: 10.1038/nri3070.

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