Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0298)
HIF Name
Human drosomycin-like defensin
HIF Synonym(s)
Human Drosomycin-Like Defensin, DLD
HIF Classification
Antimicrobial peptide (AMP)
Description Human drosomycin-like defensin has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
External Links
APD ID
AP00831
Microbe Species (MIC) Regulated by This HIF
         Aspergillus fumigatus (ascomycetes) MIC00103
             Description Human drosomycin-like defensin exerted strong fungicidal effects against the important human pathogen Aspergillus fumigatus. [2]
         Candida albicans (budding yeasts) MIC00317
             Description Neither Human drosomycin-like defensin nor drosomycin was active against the yeasts Candida albicans. [2]
         Cryptococcus neoformans (basidiomycetes) MIC00472
             Description Neither Human drosomycin-like defensin nor drosomycin was active against Cryptococcus neoformans. [2]
         Enterococcus faecalis (firmicutes) MIC00548
             Description Neither Human drosomycin-like defensin nor drosomycin was active against bacteria Enterococcus faecalis. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description Neither Human drosomycin-like defensin nor drosomycin was active against the bacteria Escherichia coli. [2]
         Fusarium (ascomycetes) MIC01796
             Description Human drosomycin-like defensin exerted strong fungicidal effects against Fusarium. [2]
         Rhizopus (fungi) MIC01792
             Description Human drosomycin-like defensin exerted strong fungicidal effects against the important Rhizopus spp. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description Human drosomycin-like defensin was active against the bacteria Staphylococcus aureus. [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity.Antimicrob Agents Chemother. 2008 Apr;52(4):1407-12. doi: 10.1128/AAC.00155-07. Epub 2008 Jan 22.

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