General Information of MIC (ID: MIC00472)
MIC Name	Cryptococcus neoformans (basidiomycetes)
MIC Synonyms	Blastomyces neoformans
Body Site	Lung
Lineage	Kingdom: Eukaryota Phylum: Basidiomycota Class: Tremellomycetes Order: Tremellales Family: Cryptococcaceae Genus: Cryptococcus Species: Cryptococcus neoformans
Oxygen Sensitivity	Anaerobe
Microbial Metabolism	Fermentative
Gram	Negative
Description	Cryptococcus neoformans is an encapsulated yeast and an obligate aerobe that can live in both plants and animals.
External Links	Taxonomy ID	5207
	Genome Assembly ID	ASM1105754v1
	GOLD Organism ID	Go0384930

Host Genetic Factors (HGFs)
hsa-miR-146a-5p
HGF ID	HGF0252	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The expression of miR-146a was rapidly induced by 3.5-fold at 3 h, upon Cryptococcus neoformans infection.				[1]

Host Immune Factors (HIFs)
Human MUC7 20-Mer
HIF ID	HIFM0304	HIF Info	Class	Antimicrobial peptide (AMP)
Description	Human MUC7 20-Mer could kill the enzymatic activity of Cryptococcus neoformans.				[2]
Human drosomycin-like defensin
HIF ID	HIFM0298	HIF Info	Class	Antimicrobial peptide (AMP)
Description	Neither Human drosomycin-like defensin nor drosomycin was active against Cryptococcus neoformans.				[3]
Immunoglobulin M
HIF ID	HIFM0266	HIF Info	Class	Immunoglobulin (Ig)
Description	IgM could provide a component of protective immunity in Cryptococcus neoformans infection.				[4]
Monocytes
HIF ID	HIFC0024	HIF Info	Class	Monocytes (Mono)
Description	Recruitment of monocytes is essential for effective control and clearance of Cryptococcus neoformans.				[5]

Environmental Factor(s)
Disbiome ID			947
aBiofilm Organism			Cryptococcus neoformans

References
1	Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection. Kiga K, Mimuro H, Suzuki M, Shinozaki-Ushiku A, Kobayashi T, Sanada T, Kim M, Ogawa M, Iwasaki YW, Kayo H, Fukuda-Yuzawa Y, Yashiro M, Fukayama M, Fukao T, Sasakawa C.. Nat Commun. 2014 Sep 4;5:4497. doi: 10.1038/ncomms5497.
2	MUC7 20-Mer: investigation of antimicrobial activity, secondary structure, and possible mechanism of antifungal action.Antimicrob Agents Chemother. 2003 Feb;47(2):643-52. doi: 10.1128/aac.47.2.643-652.2003.
3	Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity.Antimicrob Agents Chemother. 2008 Apr;52(4):1407-12. doi: 10.1128/AAC.00155-07. Epub 2008 Jan 22.
4	IgM in microbial infections: taken for granted. Immunol Lett. 2009 Aug 15;125(2):79-85. doi: 10.1016/j.imlet.2009.06.003. Epub 2009 Jun 17.
5	Monocyte recruitment during infection and inflammation.Nat Rev Immunol. 2011 Oct 10;11(11):762-74. doi: 10.1038/nri3070.

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