Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01118)
MIC Name Roseburia intestinalis (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Roseburia
Species: Roseburia intestinalis
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative; Acetate converted to butyrate
Gram Positive
Host Relationship Commensal
Genome Size (bp) 4380675
Description Roseburia intestinalis is a obligate anaerobic, Gram-positive, non-spore forming, slightly curved rod-shaped bacterium first isolated from human faeces.
External Links Taxonomy ID
166486
Genome Assembly ID
ASM15653v1
GOLD Organism ID
Go0003375
Disease Relevance
          Atherosclerotic cardiovascular disease  [ICD-11: BA5Z]
             Description Roseburia intestinalis was associated with genetic variants in Atherosclerotic cardiovascular disease. [1]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Roseburia intestinalis was associated with genetic variants in Type 2 diabetes. [1]
Host Genetic Factors (HGFs)
          HIF1A-AS2
             HGF ID HGF0524 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description The level of lncRNA (HIF1A-AS2) expression was significantly upregulated by Roseburia intestinalis flagellin (p-value<0.05). [2]
Host Immune Factors (HIFs)
          B cells
             HIF ID HIFC0001 HIF Info       Class B cells (BCs)
             Description Pathogenic autoreactive B cells cross-react with mimotopes expressed by Roseburia intestinalis to trigger autoimmunity. [3]
          Cytotoxic T-lymphocyte-associated protein 4
             HIF ID HIFM0068 HIF Info       Class Checkpoint molecule (CM)
             Description The abundance of Roseburia intestinalis(of the Clostridiales order) have been negatively associated with response to anti-CTLA-4 therapy. [4]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Roseburia intestinalis led to a significant reduction in the protein expression of IL-6(P<0.01). [5]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Roseburia intestinalis supernatant suppressed expression of interleukin (IL) 6 and signal transducer and activator of transcription 3 (STAT3) by macrophages. [5]
          Signal transducer and activator of transcription 3 signaling pathway
             HIF ID HIFP0038 HIF Info       Class Signaling pathway (SP)
             Description Roseburia intestinalis supernatant suppressed expression of interleukin (IL)-6 and signal transducer and activator of transcription 3 (STAT3) by macrophages. [5]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Roseburia intestinalis supernatant ameliorated inflammatory bowel disease colitis by reducing the number of Th17 cells in the colon. [5]
Environmental Factor(s)
             Disbiome ID
      57
             gutMDisorder ID
      gm0574
References
1 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
2 Roseburia intestinalis-derived flagellin is a negative regulator of intestinal inflammation. Biochem Biophys Res Commun. 2018 Jun 27;501(3):791-799. doi: 10.1016/j.bbrc.2018.05.075. Epub 2018 May 18.
3 Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity.Cell Host Microbe. 2019 Jul 10;26(1):100-113.e8. doi: 10.1016/j.chom.2019.05.003. Epub 2019 Jun 18.
4 The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.
5 Roseburia intestinalis supernatant ameliorates colitis induced in mice by regulating the immune response. Mol Med Rep. 2019 Aug;20(2):1007-1016. doi: 10.3892/mmr.2019.10327. Epub 2019 Jun 4.

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