Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0038)
HIF Name	Signal transducer and activator of transcription 3 signaling pathway
HIF Synonym(s)	activator of transcription 3, STAT3 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	STAT3 signaling pathway can be activated by cytokines, growth factors, and other factors to act on specific DAN fragments in the nucleus, regulating the transcriptional expression of many target genes related to cell proliferation, differentiation and apoptosis.	[1]

Microbe Species (MIC) Regulated by This HIF
Roseburia intestinalis (firmicutes)		MIC01118
Description	Roseburia intestinalis supernatant suppressed expression of interleukin (IL)-6 and signal transducer and activator of transcription 3 (STAT3) by macrophages.		[2]
Ruminococcus lactaris (firmicutes)		MIC01138
Description	At the species level, Ruminococcus lactaris is associated with STAT3.		[2]
Trichophyton interdigitale (ascomycetes)		MIC01329
Description	Invasive dermatophyte infection with Trichophyton interdigitale is associated with prurigo-induced pseudoperforation and a signal transducer and activator of transcription 3 mutation		[3]

References
1	STAT3 signaling pathway is involved in decitabine induced biological phenotype regulation of acute myeloid leukemia cells. Am J Transl Res. 2015 Oct 15;7(10):1896-907. eCollection 2015.
2	Roseburia intestinalis supernatant ameliorates colitis induced in mice by regulating the immune response. Mol Med Rep. 2019 Aug;20(2):1007-1016. doi: 10.3892/mmr.2019.10327. Epub 2019 Jun 4.
3	Invasive dermatophyte infection with Trichophyton interdigitale is associated with prurigo-induced pseudoperforation and a signal transducer and activator of transcription 3 mutation. Br J Dermatol. 2018 Sep;179(3):750-754. doi: 10.1111/bjd.15781. Epub 2018 Mar 5.

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