Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0068)
HIF Name
Cytotoxic T-lymphocyte-associated protein 4
HIF Synonym(s)
CD152, CTLA-4
HIF Classification
Checkpoint molecule (CM)
Description CTLA-4 plays a major role in preventing overactivation of host immune system and in keeping immunological homeostasis and tolerance by being expressed "at appropriate timing" and on "appropriate cell types". [1]
Pfam Immunoglobulin V-set domain (PF07686 )
Pathway Autoimmune thyroid disease (hsa05320 )
Cell adhesion molecules (CAMs) (hsa04514 )
Rheumatoid arthritis (hsa05323 )
T cell receptor signaling pathway (hsa04660 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CTLA4_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Anaerotruncus colihominis (firmicutes) MIC00087
             Description The abundance of Anaerotruncus colihominis(of the Ruminococcaceae family) have been negatively associated with response to anti-CTLA-4 therapy. [2]
         Bacteroides caccae (CFB bacteria) MIC00148
             Description The abundance of Bacteroides caccae has been associated with response to anti-CTLA-4 therapy in melanoma patients. [2]
         Bacteroides fragilis (CFB bacteria) MIC00158
             Description The efficacy of CTLA-4 blockade therapy against melanoma is associated with some enteric bacteria,such as Bacteroides fragilis. [1]
         Bacteroides thetaiotaomicron (CFB bacteria) MIC00179
             Description Oral feeding with Bacteroides thetaiotaomicron recovered anti-CTLA-4 response. [2]
         Blautia obeum (firmicutes) MIC00240
             Description Anti-CTLA-4 therapy in another melanoma cohort has been associated with baseline abundance in Ruminococcus obeum. [2]
         Burkholderia cepacia (beta-proteobacteria) MIC00281
             Description Intestinal reconstitution of antibiotic-treated mice with Burkholderia cepacia was shown to reduce anti-CTLA-4-induced colitis. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description Changes in CTLA-4 activity regulate the abundance of Escherichia coli. [2]
         Parabacteroides distasonis (CFB bacteria) MIC00949
             Description The abundance of Parabacteroides distasonis(of the Bacteroidales order) have been associated with response to CTLA-4 blockade in humans. [2]
         Parabacteroides merdae (CFB bacteria) MIC00951
             Description The abundance of Parabacteroides merdae(of the Bacteroidales order) have been associated with response to CTLA-4 blockade in humans. [2]
         Roseburia intestinalis (firmicutes) MIC01118
             Description The abundance of Roseburia intestinalis(of the Clostridiales order) have been negatively associated with response to anti-CTLA-4 therapy. [2]
References
1 Microbial biomarkers for immune checkpoint blockade therapy against cancer.J Gastroenterol. 2018 Sep;53(9):999-1005. doi: 10.1007/s00535-018-1492-9. Epub 2018 Jul 12.
2 The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.

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