| General Information of MIC (ID: MIC00951) |
| MIC Name |
Parabacteroides merdae (CFB bacteria)
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| MIC Synonyms |
Bacteroides merdae
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| Body Site |
Gut
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| Lineage |
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Tannerellaceae
Genus: Parabacteroides
Species: Parabacteroides merdae
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| Oxygen Sensitivity |
Anaerobe
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| Gram |
Negative
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| Host Relationship |
Commensal
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| Genome Size (bp) |
4431877
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| Description |
Parabacteroides merdae is also known as Bacteroides merdae. It is a obligately anaerobic, Gram-negative, rod shaped bacterium.
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| External Links |
Taxonomy ID |
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| Genome Assembly ID |
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| GOLD Organism ID |
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| Disease Relevance |
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| Inflammatory bowel disease [ICD-11: DD72] |
| Description |
Bacteroides merdae was associated with inflammatory bowel disease. |
[1] |
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| Host Immune Factors (HIFs) |
| Cytotoxic T-lymphocyte-associated protein 4 |
| HIF ID |
HIFM0068 |
HIF Info
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Class |
Checkpoint molecule (CM) |
| Description |
The abundance of Parabacteroides merdae(of the Bacteroidales order) have been associated with response to CTLA-4 blockade in humans. |
[2] |
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| Environmental Factor(s) |
| Disbiome ID |
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| gutMDisorder ID |
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| References |
| 1 |
Detection of B. fragilis group and diversity of bft enterotoxin and antibiotic resistance markers cepA, cfiA and nim among intestinal Bacteroides fragilis strains in patients with inflammatory bowel disease. Anaerobe. 2018 Apr;50:93-100. doi: 10.1016/j.anaerobe.2018.02.005. Epub 2018 Feb 14.
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| 2 |
The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.
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