General Information of MIC (ID: MIC00087)
MIC Name	Anaerotruncus colihominis (firmicutes)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Ruminococcaceae Genus: Anaerotruncus Species: Anaerotruncus colihominis
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Positive
Host Relationship	Commensal
Genome Size (bp)	371888
Description	Anaerotruncus colihominis is a Gram-positive, non-spore-forming, rod-shaped and anaerobic bacterium from the genus of Anaerotruncus which occur in human faeces.
External Links	Taxonomy ID	169435
	Genome Assembly ID	ASM15456v1
	GOLD Organism ID	Go0001937
Disease Relevance
Gestational diabetes mellitus  [ICD-11: JA63]
Description	Genus Anaerotruncus was increased in children of women with GDM(Gestational diabetes mellitus).				[1]
Rheumatoid arthritis  [ICD-11: FA20]
Description	The relative abundance of Anaerotruncus colihominis was low in Rheumatoid arthritis.				[2]

Host Genetic Factors (HGFs)
15q11-13
HGF ID	HGF2318	HGF Info	Class	Copy Number Variation: Gene Duplication (CNV-GDu)
Description	There has a significantly different abundance of Anaerotruncus colihominis between 15q dup mice and wide type littermates (p-value=0.0236).				[3]
rs6111497
HGF ID	HGF1622	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs6111497 SNP was significantly associated with the abundance of Anaerotruncus (p-value=1.99E-06).				[4]
rs6080636
HGF ID	HGF1623	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs6080636 SNP was significantly associated with the abundance of Anaerotruncus (p-value=1.99E-06).				[4]
rs4342104
HGF ID	HGF2084	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs4342104 SNP was significantly associated with the abundance of Anaerotruncus (p-value=0.04453).				[5]
rs2108370
HGF ID	HGF1608	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs2108370 SNP was significantly associated with the abundance of Anaerotruncus (p-value=2.30E-05).				[4]
rs11696277
HGF ID	HGF1624	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs11696277 SNP was significantly associated with the abundance of Anaerotruncus (p-value=1.99E-06).				[4]

Host Immune Factors (HIFs)
Cytotoxic T-lymphocyte-associated protein 4
HIF ID	HIFM0068	HIF Info	Class	Checkpoint molecule (CM)
Description	The abundance of Anaerotruncus colihominis(of the Ruminococcaceae family) have been negatively associated with response to anti-CTLA-4 therapy.				[6]

Environmental Factor(s)
Disbiome ID			1635
gutMDisorder ID			gm0053

References
1	Gut microbiome in gestational diabetes: a cross-sectional study of mothers and offspring 5 years postpartum. Acta Obstet Gynecol Scand. 2018 Jan;97(1):38-46. doi: 10.1111/aogs.13252.
2	Comparative Analysis of Fecal Microbiota Composition Between Rheumatoid Arthritis and Osteoarthritis Patients. Genes (Basel). 2019 Sep 25;10(10):748. doi: 10.3390/genes10100748.
3	Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice.Neurosci Res. 2019 Dec 18:S0168-0102(19)30671-6. doi: 10.1016/j.neures.2019.12.010. Online ahead of print.
4	Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
5	FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects.Gut Microbes. 2018 Jul 4;9(4):357-368. doi: 10.1080/19490976.2018.1445956. Epub 2018 Apr 27.
6	The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.

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