Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00148)
MIC Name Bacteroides caccae (CFB bacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides caccae
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 4564814
Description Bacteroides caccae is an anaerobic, Gram-negative, non spore-forming and rod-shaped bacterium. It was isolated from human feces that is associated with inflammatory bowel diseases of a healthy individual. This bacterium involved in inflammatory bowel diseases of human.
External Links Taxonomy ID
47678
Genome Assembly ID
ASM16901v1
GOLD Organism ID
Go0000883
Disease Relevance
          Attention deficit hyperactivity disorder  [ICD-11: 6A05]
             Description Bacteroides caccae was increased in attention-deficit/hyperactivity disorder. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Inflammatory bowel disease was associated with Bacteroides caccae. [2]
Host Genetic Factors (HGFs)
          CD44
             HGF ID HGF2333 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of CD44 significantly decreased the abundance of Bacteroides caccae (p-value<0.05). [3]
          SMARCAD1
             HGF ID HGF2342 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of SMARCAD1 was significantly associated with a decrease of Bacteroides caccae (p-value<0.05). [4]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The higher AMY1-CN has been associated with the abundance of Bacteroides caccae. [5]
          rs7903146
             HGF ID HGF1295 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The variant gene TCF7L2 of innate immunity rs7903146 is significantly associated with the abundance of gut micriobiota Bacteroides caccae (p-value=0.0018). [6]
          rs12722515
             HGF ID HGF2601 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12722515 SNP is associated with the abundance of Bacteroides caccae. [7]
          rs7517810
             HGF ID HGF2531 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7517810 SNP is associated with the abundance of Bacteroides caccae. [7]
          rs6088765
             HGF ID HGF2602 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6088765 SNP is associated with the abundance of Bacteroides caccae. [7]
Host Immune Factors (HIFs)
          Cytotoxic T-lymphocyte-associated protein 4
             HIF ID HIFM0068 HIF Info       Class Checkpoint molecule (CM)
             Description The abundance of Bacteroides caccae has been associated with response to anti-CTLA-4 therapy in melanoma patients. [8]
          Programmed Cell Death 1 Protein
             HIF ID HIFM0191 HIF Info       Class Checkpoint molecule (CM)
             Description The baseline enrichment in Bacteroides caccae has been associated with response to anti-PD-1 therapy in melanoma patients. [8]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Bacteroides caccae at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease. [9]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Bacteroides caccae is associated with the IgA. [2]
          FOXP3+ regulatory T cells
             HIF ID HIFC0033 HIF Info       Class T cells (TCs)
             Description Bacteroides caccae has been shown to induce the accumulation of FOXP3+ pTreg cells. [10]
          CD103+NRP1 FOXP3+CD4+ regulatory T cells
             HIF ID HIFC0185 HIF Info       Class T cells (TCs)
             Description Bacteroides caccae is related to the increase of CD103+NRP1FOXP3+CD4+ Treg cells in the colon. [10]
          NRP1 RORt+ regulatory T cells
             HIF ID HIFC0224 HIF Info       Class T cells (TCs)
             Description Bacteroides caccae has been shown to induce the accumulation number of NRP1RORt+ pTreg cells. [10]
Environmental Factor(s)
             Disbiome ID
      595
             gutMDisorder ID
      gm0079
References
1 Case-Control Study of the Effects of Gut Microbiota Composition on Neurotransmitter Metabolic Pathways in Children With Attention Deficit Hyperactivity Disorder. Front Neurosci. 2020 Feb 18;14:127. doi: 10.3389/fnins.2020.00127. eCollection 2020.
2 Molecular cloning of a Bacteroides caccae TonB-linked outer membrane protein identified by an inflammatory bowel disease marker antibody. Infect Immun. 2001 Oct;69(10):6044-54. doi: 10.1128/IAI.69.10.6044-6054.2001.
3 CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice.Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792. Epub 2017 Jun 6.
4 Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium.Genome Biol. 2020 Mar 11;21(1):64. doi: 10.1186/s13059-020-01976-7.
5 Pretreatment Prevotella-to-Bacteroides ratio and salivary amylase gene copy number as prognostic markers for dietary weight loss.Am J Clin Nutr. 2020 May 1;111(5):1079-1086. doi: 10.1093/ajcn/nqaa007.
6 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
7 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
8 The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.
9 Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.
10 Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.

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