Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00281)
MIC Name Burkholderia cepacia (beta-proteobacteria)
MIC Synonyms Pseudomonas cepacia
Body Site Lung
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Burkholderia
Species: Burkholderia cepacia
Oxygen Sensitivity Aerobe
Microbial Metabolism Glycolysis
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 8605945
No. of Coding Genes 7510
No. of Non-Coding Genes 83
No. of Small Non-Coding Genes 83
No. of Gene Transcripts 7593
No. of Base Pairs 8947129
Description Burkholderia cepacia is an aerobic, Gram-negative bacterium. B. cepacia is an opportunistic human pathogen that most often causes pneumonia in immunocompromised individuals with underlying lung disease. Patients with sickle-cell haemoglobinopathies are also at risk.
External Links Taxonomy ID
292
Genome Assembly ID
ASM72497v1
GOLD Organism ID
Go0001983
Disease Relevance
          Granulomatous disease  [ICD-11: 4A00]
             Description Burkholderia cepacia can cause chronic granulomatous disease. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Burkholderia cepacia is associated with inflammatory bowel disease. [2]
          Lymphadenitis  [ICD-11: BD90]
             Description Burkholderia cepacia can cause lymphadenitis. [1]
          Skin abscesses  [ICD-11: 1B75]
             Description Burkholderia cepacia can cause cutaneous abscesses. [1]
Host Immune Factors (HIFs)
          Cytotoxic T-lymphocyte-associated protein 4
             HIF ID HIFM0068 HIF Info       Class Checkpoint molecule (CM)
             Description Intestinal reconstitution of antibiotic-treated mice with Burkholderia cepacia was shown to reduce anti-CTLA-4-induced colitis. [3]
Environmental Factor(s)
             Disbiome ID
      708
             gutMDisorder ID
      gm0131
             aBiofilm Organism
      Burkholderia cepacia
References
1 Chronic granulomatous disease. Br Med Bull. 2016 Jun;118(1):50-63. doi: 10.1093/bmb/ldw009. Epub 2016 Mar 16.
2 Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases. Microbiome. 2019 Jan 3;7(1):1. doi: 10.1186/s40168-018-0604-3.
3 The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.

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