General Information of MIC (ID: MIC01961)
MIC Name	Oscillibacter valericigenes (firmicutes)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Oscillospiraceae Genus: Oscillibacter Species: Oscillibacter valericigenes
Oxygen Sensitivity	Anaerobe
Microbial Metabolism	Fermentative
Gram	Negative
Description	Oscillibacter valericigenes is a Gram-negative and anaerobic bacterium. O. valericigenes has been detected in the human intestinal microbiome. In one study of human gut microflora, O. valericigenes was found in significantly more samples from healthy control test subjects than from patients diagnosed with Crohn's disease.
External Links	Taxonomy ID	351091
	Genome Assembly ID	ASM28357v1
	GOLD Organism ID	Go0001120
Disease Relevance
Crohn disease  [ICD-11: DD70]
Description	Uncultivated Oscillibacter strains have been previously found to be anti-correlated with Crohn's disease.				[1]
Depression  [ICD-11: 6A70]
Description	Oscillibacter was identified by more than one report as elevated in major depressive disorder.				[2]
Non-alcoholic fatty liver disease  [ICD-11: DB92]
Description	Nonalcoholic fatty liver disease was associated with Oscillibacter infection.				[3]
Obesity  [ICD-11: 5B81]
Description	Oscillibacter valericigenes was associated with genetic variants in Obesity.				[4]

Host Genetic Factors (HGFs)
15q11-13
HGF ID	HGF2318	HGF Info	Class	Copy Number Variation: Gene Duplication (CNV-GDu)
Description	There has a significantly different abundance of Oscillibacter valericigenes between 15q dup mice and wild type littermates (p-value=0.0167).				[5]
MIR21
HGF ID	HGF2332	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of MIR-21 was significantly increased the abundance of Oscillibacter (p-value<0.05).				[6]
KLB
HGF ID	HGF2334	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of KLB reduced the proportion of Oscillibacter.				[7]

Host Immune Factors (HIFs)
Interleukin-1 beta
HIF ID	HIFM0138	HIF Info	Class	Cytokine (Cyt)
Description	The Oscillibacter abundance was significantly positively correlated with IL-1beta levels.				[8]
Interferon-6
HIF ID	HIFM0151	HIF Info	Class	Cytokine (Cyt)
Description	Oscillibacter abundance was significantly positively correlated with IL-6.				[8]

Environmental Factor(s)
Disbiome ID			1576
gutMDisorder ID			gm0484

References
1	Cultivation-based multiplex phenotyping of human gut microbiota allows targeted recovery of previously uncultured bacteria. Nat Commun. 2014 Aug 28;5:4714. doi: 10.1038/ncomms5714.
2	Systematic Review of Gut Microbiota and Major Depression. Front Psychiatry. 2019 Feb 11;10:34. doi: 10.3389/fpsyt.2019.00034. eCollection 2019.
3	Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2013 Jul;11(7):868-75.e1-3. doi: 10.1016/j.cgh.2013.02.015. Epub 2013 Feb 27.
4	M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
5	Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice.Neurosci Res. 2019 Dec 18:S0168-0102(19)30671-6. doi: 10.1016/j.neures.2019.12.010. Online ahead of print.
6	Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.J Crohns Colitis. 2018 Jun 28;12(7):835-848. doi: 10.1093/ecco-jcc/jjy038.
7	-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue.JCI Insight. 2017 Apr 20;2(8):e91809. doi: 10.1172/jci.insight.91809. eCollection 2017 Apr 20.
8	Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota. Pharmacol Res. 2019 Dec;150:104489. doi: 10.1016/j.phrs.2019.104489. Epub 2019 Nov 2.

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