Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01231)
MIC Name Stenotrophomonas maltophilia (gamma-proteobacteria)
MIC Synonyms Pseudomonas maltophilia
Body Site Lung
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Xanthomonadales
Family: Xanthomonadaceae
Genus: Stenotrophomonas
Species: Stenotrophomonas maltophilia
Oxygen Sensitivity Aerobe
Microbial Metabolism Nonfermentative
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 4509724
No. of Coding Genes 4543
No. of Non-Coding Genes 74
No. of Small Non-Coding Genes 74
No. of Gene Transcripts 4617
No. of Base Pairs 4989312
Description Stenotrophomonas maltophilia is an aerobic, Gram negative, motile, non-fermentative bacillus previously known as Pseudomonas maltophilia and Xanthomonas maltophilia. Although an uncommon pathogen in humans, S maltophilia infection in humans, especially nosocomial, has been increasingly recognized. It is emerging as an opportunistic, nosocomial pathogen associated with a high mortality rate.
External Links Taxonomy ID
40324
Genome Assembly ID
ASM74299v1
GOLD Organism ID
Go0005554
Disease Relevance
          Cystic fibrosis  [ICD-11: CA25]
             Description Stenotrophomonas maltophilia is a Gram-negative opportunistic pathogen that can infect the lungs of people with cystic fibrosis (CF). [1]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Stenotrophomonas maltophilia was associated with type 2 diabetes. [2]
Host Immune Factors (HIFs)
          Human beta defensin 3
             HIF ID HIFM0079 HIF Info       Class Antimicrobial peptide (AMP)
             Description HBD-3 of 8g/ml against Stenotrophomonas maltophilia nosocomial strains bactericidal activity with defined resistance phenotypes such as amikacin. [3]
          Interleukin-1 alpha
             HIF ID HIFM0137 HIF Info       Class Cytokine (Cyt)
             Description Stenotrophomonas maltophilia infection induces a significantly higher proinflammatory cytokine response such as IL-1alpha at 100pg/ml(p<0.01). [4]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description The vaccination with rOmpA significantly reduced the levels of IL-6(P<0.01) in BALF after respiratory Stenotrophomonas maltophilia challenge in mice. [5]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Vaccination with rOmpA significantly reduced the levels of TNF-Alpha and IL-6 in BALF at 24 hours after respiratory Stenotrophomonas maltophilia challenge in mice. [5]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Intranasal immunization with Stenotrophomonas maltophilia recombinant OmpA may trigger Th1-mediated cellular immune responses. [5]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Intranasal immunization with Stenotrophomonas maltophilia recombinant OmpA may trigger Th17-mediated cellular immune responses. [5]
Environmental Factor(s)
             Disbiome ID
      641
             gutMDisorder ID
      gm0622
             aBiofilm Organism
      Stenotrophomonas maltophilia
References
1 Stenotrophomonas maltophilia Differential Gene Expression in Synthetic Cystic Fibrosis Sputum Reveals Shared and Cystic Fibrosis Strain-Specific Responses to the Sputum Environment. J Bacteriol. 2019 Jul 10;201(15):e00074-19. doi: 10.1128/JB.00074-19. Print 2019 Aug 1.
2 Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis. Nat Commun. 2017 Jun 6;8:15393. doi: 10.1038/ncomms15393.
3 Expression and antimicrobial character of cells transfected with human defensin3 against periodontitisassociated microbiota in vitro.Mol Med Rep. 2017 Sep;16(3):2455-2460. doi: 10.3892/mmr.2017.6913. Epub 2017 Jul 4.
4 Cooperativity between Stenotrophomonas maltophilia and Pseudomonas aeruginosa during Polymicrobial Airway Infections. Infect Immun. 2020 Mar 23;88(4):e00855-19. doi: 10.1128/IAI.00855-19. Print 2020 Mar 23.
5 Intranasal immunization with recombinant outer membrane protein A induces protective immune response against Stenotrophomonas maltophilia infection. PLoS One. 2019 Apr 1;14(4):e0214596. doi: 10.1371/journal.pone.0214596. eCollection 2019.

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