Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0079)
HIF Name
Human beta defensin 3
HIF Synonym(s)
Human Beta Defensin 3, hBD-3, hBD3, DEFB103, Beta-defensin 103, BD-3
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antibiotic; Antimicrobial; Defensin
Description Human beta defensin 3 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Beta defensin (PF00711 )
Pathway NOD-like receptor signaling pathway (hsa04621 )
Staphylococcus aureus infection (hsa05150 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
D103A_HUMAN
APD ID
AP00284
Microbe Species (MIC) Regulated by This HIF
         Acinetobacter baumannii (gamma-proteobacteria) MIC00016
             Description HBD-3 of 4g/ml against Acinetobacter baumannii nosocomial strains bactericidal activity with defined resistance phenotypes such as amoxycillin. [2]
         Candida glabrata (budding yeasts) MIC01794
             Description The expression of HBD-3 are upregulated in Candida esophagitis. [3]
         Enterococcus faecium (firmicutes) MIC00549
             Description HBD-3 of 8g/ml against Enterococcus faecium nosocomial strains bactericidal activity with defined resistance phenotypes such as amoxycillin. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description The expression of HBD3 increases the cellular uptake of Escherichia coli and self-DNA into mouse Flt-3 induced dendritic cells (FLDCs) (p-value<0.01). [4]
         Pseudomonas aeruginosa (gamma-proteobacteria) MIC01054
             Description HBD-3 of 8g/ml against Pseudomonas aeruginosa nosocomial strains bactericidal activity with defined resistance phenotypes such as amoxycillin. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description HBD-3 of 4g/ml against Staphylococcus aureus nosocomial strains bactericidal activity with defined resistance phenotypes such as amoxycillin. [2]
         Stenotrophomonas maltophilia (gamma-proteobacteria) MIC01231
             Description HBD-3 of 8g/ml against Stenotrophomonas maltophilia nosocomial strains bactericidal activity with defined resistance phenotypes such as amikacin. [2]
         Streptococcus mutans (firmicutes) MIC01258
             Description Streptococcus mutans was susceptible to HBD-3. [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Expression and antimicrobial character of cells transfected with human defensin3 against periodontitisassociated microbiota in vitro.Mol Med Rep. 2017 Sep;16(3):2455-2460. doi: 10.3892/mmr.2017.6913. Epub 2017 Jul 4.
3 The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis.BMC Immunol. 2009 Jun 12;10:36. doi: 10.1186/1471-2172-10-36.
4 -Defensins: Farming the Microbiome for Homeostasis and Health.Front Immunol. 2019 Jan 25;9:3072. doi: 10.3389/fimmu.2018.03072. eCollection 2018.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.