Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00016)
MIC Name Acinetobacter baumannii (gamma-proteobacteria)
MIC Synonyms Acinetobacter genomosp. 2
Body Site Blood
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Moraxellaceae
Genus: Acinetobacter
Species: Acinetobacter baumannii
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 3947488
No. of Coding Genes 3475
No. of Non-Coding Genes 79
No. of Small Non-Coding Genes 79
No. of Gene Transcripts 3630
No. of Pseudogenes 76
No. of Base Pairs 3844542
Description Acinetobacter baumannii is an aerobic, Gram-negative, almost round, rod-shaped, typically short bacterium. It can be an opportunistic pathogen in humans, affecting people with compromised immune systems, and is becoming increasingly important as a hospital-derived infection.
External Links Taxonomy ID
470
Genome Assembly ID
ASM144671v1
GOLD Organism ID
Go0004745
Disease Relevance
          Pneumonia  [ICD-11: CA40]
             Description Acinetobacter baumanii was associated with ventilator associated pneumonia. [1]
Host Genetic Factors (HGFs)
          hsa-miR-AbsRNA5
             HGF ID HGF0629 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-AbsRNA5 can regulate host-microbe Acinetobacter baumannii interactions that shape the pathogenesis of Acinetobacter baumannii infection mediated by the host immune response. [2]
          hsa-miR-AbsRNA4
             HGF ID HGF0628 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-AbsRNA4 targeted A1S_0501 which was previously listed as a transcript that decreased significantly upon exposure to NaCl in Acinetobacter baumanii. [2]
Host Immune Factors (HIFs)
          Human beta defensin 3
             HIF ID HIFM0079 HIF Info       Class Antimicrobial peptide (AMP)
             Description HBD-3 of 4g/ml against Acinetobacter baumannii nosocomial strains bactericidal activity with defined resistance phenotypes such as amoxycillin. [3]
          Human beta defensin 114
             HIF ID HIFM0082 HIF Info       Class Antimicrobial peptide (AMP)
             Description The expression of DEFB114 showed negative correlations with the abundance of Acinetobacter baumannii. [4]
          Eosinophil cationic protein
             HIF ID HIFM0094 HIF Info       Class Antimicrobial peptide (AMP)
             Description The RNase 3 showed >10 bactericidal activity against Acinetobacter baumannii when the hemolytic activity of 11.2+0.1M or 11.2-0.1M and the peptide size reduction of 48%. [5]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Caspase-11 deficiency aggravated the pulmonary inflammatory response to Acinetobacter baumannii infection, which was characterized by extensive neutrophil infiltration and consolidation. [6]
          Caspase-1-Sirt1-AP-1 signaling pathway
             HIF ID HIFP0004 HIF Info       Class Signaling pathway (SP)
             Description Acinetobacter baumannii could trigger the caspase-1 pathway. [6]
          Interleukin 1 signaling pathway
             HIF ID HIFP0018 HIF Info       Class Signaling pathway (SP)
             Description Acinetobacter baumannii could trigger the IL-1Beta pathway. [6]
          Interleukin 17 signaling pathway
             HIF ID HIFP0013 HIF Info       Class Signaling pathway (SP)
             Description At the species level, Acinetobacter baumannii is associated with The interleukin-17 (IL-17) pathway. [6]
Environmental Factor(s)
             Disbiome ID
      1275
             gutMDisorder ID
      gm0012
             aBiofilm Organism
      Acinetobacter baumannii
References
1 World-wide variation in incidence of Acinetobacter associated ventilator associated pneumonia: a meta-regression. BMC Infect Dis. 2016 Oct 18;16(1):577. doi: 10.1186/s12879-016-1921-4.
2 COL(R) Acinetobacter baumannii sRNA Signatures: Computational Comparative Identification and Biological Targets. Front Microbiol. 2020 Jan 17;10:3075. doi: 10.3389/fmicb.2019.03075. eCollection 2019.
3 Expression and antimicrobial character of cells transfected with human defensin3 against periodontitisassociated microbiota in vitro.Mol Med Rep. 2017 Sep;16(3):2455-2460. doi: 10.3892/mmr.2017.6913. Epub 2017 Jul 4.
4 Evaluating the Value of Defensins for Diagnosing Secondary Bacterial Infections in Influenza-Infected Patients.Front Microbiol. 2018 Nov 20;9:2762. doi: 10.3389/fmicb.2018.02762. eCollection 2018.
5 Exploring the mechanisms of action of human secretory RNase 3 and RNase 7 against Candida albicans.Microbiologyopen. 2016 Oct;5(5):830-845. doi: 10.1002/mbo3.373. Epub 2016 Jun 8.
6 Caspase-11 Plays a Protective Role in Pulmonary Acinetobacter baumannii Infection. Infect Immun. 2017 Sep 20;85(10):e00350-17. doi: 10.1128/IAI.00350-17. Print 2017 Oct.

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