Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0004)
HIF Name	Caspase-1-Sirt1-AP-1 signaling pathway
HIF Synonym(s)	caspase-1 activation, Caspase-1-Sirt1-AP-1 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	Caspase-1 activation induces expression of cytokines, chemokines, and adhesion molecules via an Sirt1-AP-1-mediated pathway Our data showed that caspase-1 activation induces the upregulation of several EC activation-associated cytokines, chemokines, and endothelial adhesion molecules.	[1]

Microbe Species (MIC) Regulated by This HIF
Acinetobacter baumannii (gamma-proteobacteria)		MIC00016
Description	Acinetobacter baumannii could trigger the caspase-1 pathway.		[2]

References
1	Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):804-16. doi: 10.1161/ATVBAHA.115.305282. Epub 2015 Feb 19.
2	Caspase-11 Plays a Protective Role in Pulmonary Acinetobacter baumannii Infection. Infect Immun. 2017 Sep 20;85(10):e00350-17. doi: 10.1128/IAI.00350-17. Print 2017 Oct.

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