Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0082)
HIF Name	Human beta defensin 114
HIF Synonym(s)	Defb114, human beta defensin 114, UCSS1a
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Antibiotic; Antimicrobial; Defensin
Description	DEFB114 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.		[1]
Pfam	Beta defensin (PF13841 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	DB114_HUMAN
	APD ID	AP02188

Microbe Species (MIC) Regulated by This HIF
Acinetobacter baumannii (gamma-proteobacteria)		MIC00016
Description	The expression of DEFB114 showed negative correlations with the abundance of Acinetobacter baumannii.		[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Evaluating the Value of Defensins for Diagnosing Secondary Bacterial Infections in Influenza-Infected Patients.Front Microbiol. 2018 Nov 20;9:2762. doi: 10.3389/fmicb.2018.02762. eCollection 2018.

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