Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01258)
MIC Name Streptococcus mutans (firmicutes)
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus mutans
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 2032935
Description Streptococcus mutans is a facultatively anaerobic, Gram-positive coccus commonly found in the human oral cavity and is a significant contributor to tooth decay.
External Links Taxonomy ID
1309
Genome Assembly ID
ATCC25175_V1
GOLD Organism ID
Go0001148
Disease Relevance
          Tooth pulp necrosis  [ICD-11: DA01]
             Description Streptococcus mutans is considered the most significant contributor to tooth decay. [1]
Host Genetic Factors (HGFs)
          DMBT1
             HGF ID HGF2362 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The multiallelic copy number variation of DMBT1 is significantly associated with the abundance of Streptococcus mutans (p-value<0.05). [2]
          rs2278163
             HGF ID HGF1821 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description The rs2278163 SNP was significantly associated with the abundance of Streptococcus mutans (p-value=0.00529). [3]
Host Immune Factors (HIFs)
          Human beta defensin 3
             HIF ID HIFM0079 HIF Info       Class Antimicrobial peptide (AMP)
             Description Streptococcus mutans was susceptible to HBD-3. [4]
          Human beta-defensin 1
             HIF ID HIFM0090 HIF Info       Class Antimicrobial peptide (AMP)
             Description Streptococcus mutans is susceptibility to human beta defensin 1. [5]
Environmental Factor(s)
             Disbiome ID
      28
             gutMDisorder ID
      gm0624
             aBiofilm Organism
      Streptococcus mutans
References
1 Progress of Antimicrobial Discovery Against the Major Cariogenic Pathogen Streptococcus mutans. Curr Issues Mol Biol. 2019;32:601-644. doi: 10.21775/cimb.032.601. Epub 2019 Jun 5.
2 Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy.Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5105-10. doi: 10.1073/pnas.1416531112. Epub 2015 Apr 6.
3 Association of DLX3 gene polymorphism and dental caries susceptibility in Japanese children.Arch Oral Biol. 2015 Jan;60(1):55-61. doi: 10.1016/j.archoralbio.2014.08.020.
4 Expression and antimicrobial character of cells transfected with human defensin3 against periodontitisassociated microbiota in vitro.Mol Med Rep. 2017 Sep;16(3):2455-2460. doi: 10.3892/mmr.2017.6913. Epub 2017 Jul 4.
5 Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms.J Clin Microbiol. 2004 Mar;42(3):1024-9. doi: 10.1128/jcm.42.3.1024-1029.2004.

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