Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00710)
MIC Name Lactobacillus crispatus (firmicutes)
MIC Synonyms Eubacterium crispatum
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus crispatus
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 2043161
No. of Coding Genes 2010
No. of Non-Coding Genes 64
No. of Small Non-Coding Genes 64
No. of Gene Transcripts 2074
No. of Base Pairs 22101463
Description Lactobacillus crispatus is a common, facultative anaerobic, Gram positive, rod-shaped species of genus Lactobacillus and is a hydrogen peroxide producing beneficial micro biota species located in both the vagina, through vaginal discharge, and the vertebrate gastrointestinal.
External Links Taxonomy ID
47770
Genome Assembly ID
ASM154138v1
GOLD Organism ID
Go0004730
Disease Relevance
          Vaginitis  [ICD-11: GA02]
             Description Lactobacillus crispatus was associated with bacterial vaginosis. [1]
Host Genetic Factors (HGFs)
          rs73330467
             HGF ID HGF2635 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-UV)
             Description The single nucleotide polymorphisms rs73330467 associated with the abundance of vaginal microbiome Lactobacillus crispatus. [2]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description The Lactobacillus crispatus specifically enhances the production of the IL-10 anti-inflammatory cytokine. [3]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus crispatus and its supernatant reduced IL-6 production in Chlamydia trachomatis-infected HeLa and J774 cells. [3]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus crispatus and its supernatant reduced IL-8 production in Chlamydia trachomatis-infected HeLa and J774 cells. [3]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus crispatus and its supernatant reduced IL-6, IL-8 and TNF-Alpha production in Chlamydia trachomatis-infected HeLa and J774 cells. [3]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Fusobacterium necrophorum is associated with macrophages response. [3]
          CD44+ T helper cells
             HIF ID HIFC0155 HIF Info       Class T cells (TCs)
             Description CD44+ T helper cells were activated flowing inoculation with Lactobacillus crispatus. [4]
          CCR5+ T helper cells
             HIF ID HIFC0182 HIF Info       Class T cells (TCs)
             Description CCR5+ T helper cells were activated flowing inoculation with Lactobacillus crispatus. [4]
Environmental Factor(s)
             Disbiome ID
      388
             gutMDisorder ID
      gm0395
References
1 The urinary microbiota of men and women and its changes in women during bacterial vaginosis and antibiotic treatment. Microbiome. 2017 Aug 14;5(1):99. doi: 10.1186/s40168-017-0305-3.
2 Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation. Mol Biol Evol. 2017 Oct 1;34(10):2704-2715. doi: 10.1093/molbev/msx206.
3 Lactobacillus crispatus mediates anti-inflammatory cytokine interleukin-10 induction in response to Chlamydia trachomatis infection in vitro. Int J Med Microbiol. 2015 Dec;305(8):815-27. doi: 10.1016/j.ijmm.2015.07.005. Epub 2015 Sep 5.
4 The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017 Aug;151(4):363-374. doi: 10.1111/imm.12760. Epub 2017 Jun 20.

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