General Information of MIC (ID: MIC00705)
MIC Name	Lactobacillus brevis (firmicutes)
MIC Synonyms	Betabacterium breve
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus brevis
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Saccharolytic; Respiratory or Fermentative
Gram	Positive
Host Relationship	Probiotic
Genome Size (bp)	2340228
No. of Coding Genes	2788
No. of Non-Coding Genes	66
No. of Small Non-Coding Genes	66
No. of Gene Transcripts	2854
No. of Base Pairs	2864217
Description	Lactobacillus brevis is a facultative anaerobic, Gram-positive, rod shaped species of lactic acid bacteria which is heterofermentive, creating CO2 and lactic acid during fermentation. L.brevis is found in human intestines, vagina and faeces.
External Links	Taxonomy ID	1580
	Genome Assembly ID	ASM81472v1
	GOLD Organism ID	Go0000287
Disease Relevance
Inflammatory bowel disease  [ICD-11: DD72]
Description	Lactobacillus brevis could be used as a potential probiotic candidate in inflammatory bowel disease to decrease the disease activity index.				[1]
Schizophrenia  [ICD-11: 6A20]
Description	Lactobacillus brevis was associated with schizophrenia.				[2]

Host Genetic Factors (HGFs)
CHD1
HGF ID	HGF2336	HGF Info	Class	Copy Number Variation: Gene Deletion (CNV-GDe)
Description	The deletion of CHD1 decreased the abundance of Lactobacillaceae brevis.				[3]

Host Immune Factors (HIFs)
Interleukin-1 beta
HIF ID	HIFM0138	HIF Info	Class	Cytokine (Cyt)
Description	Heat-killed Lactobacillus brevis promoted higher gene expression levels of IL-1Beta.				[4]
Interferon-6
HIF ID	HIFM0151	HIF Info	Class	Cytokine (Cyt)
Description	Heat-killed Lactobacillus brevis promoted higher gene expression levels of IL-6.				[4]

Environmental Factor(s)
Disbiome ID			729
gutMDisorder ID			gm0393

References
1	Highly Heterogeneous Probiotic Lactobacillus Species in Healthy Iranians with Low Functional Activities. PLoS One. 2015 Dec 8;10(12):e0144467. doi: 10.1371/journal.pone.0144467. eCollection 2015.
2	The role of the gut microbiota in schizophrenia: Current and future perspectives. World J Biol Psychiatry. 2018 Dec;19(8):571-585. doi: 10.1080/15622975.2018.1433878. Epub 2018 Feb 21.
3	Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster.PLoS One. 2016 Apr 19;11(4):e0153476. doi: 10.1371/journal.pone.0153476. eCollection 2016.
4	Probiotic and Antioxidant Properties of Novel Lactobacillus brevis KCCM 12203P Isolated from Kimchi and Evaluation of Immune-Stimulating Activities of Its Heat-Killed Cells in RAW 264.7 Cells. J Microbiol Biotechnol. 2019 Dec 28;29(12):1894-1903. doi: 10.4014/jmb.1907.07081.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.