Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01010)
MIC Name Prevotella copri (CFB bacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella copri
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 3507873
Description Prevotella copri is a Gram-negative bacterium. The cells are anaerobic and do not form spores. The cells grow best at 37 degree Celsius and are rod shaped. Prevotella copri is an intestinal bacteria, and its anaerobic qualities allows it to grow successfully in the human gut and intestines. This bacterium was found associated with Inflammatory bowel disease.
External Links Taxonomy ID
165179
Genome Assembly ID
ASM15793v1
GOLD Organism ID
Go0489250
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Prevotella copri was significantly elevated in autistic children. [1]
          Autoimmune liver disease  [ICD-11: DB96]
             Description Primary sclerosing cholangitis was further characterized by decreased abundance of Prevotella copri. [2]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Prevotella copri is downregulated in inflammatory bowel disease. [2]
          Parkinsonism  [ICD-11: 8A00]
             Description Prevotella copri was associated with parkinsons disease. [3]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Prevotella copri was associated with type 2 diabetes. [4]
Host Genetic Factors (HGFs)
          SMARCAD1
             HGF ID HGF2342 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of SMARCAD1 was significantly associated with a decrease of Prevotella copri (p-value<0.05). [5]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The relative abundance of Prevotella copri, was twofold higher in adults with a high number of AMY1 copies (10) as compared to those with a low AMY1 copy number (4). [6]
Host Immune Factors (HIFs)
          Interferon-12 subunit alpha
             HIF ID HIFM0130 HIF Info       Class Cytokine (Cyt)
             Description The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-12 expression. [7]
          Interleukin-17A
             HIF ID HIFM0134 HIF Info       Class Cytokine (Cyt)
             Description The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-17A expression. [7]
          Interleukin-17F
             HIF ID HIFM0135 HIF Info       Class Cytokine (Cyt)
             Description The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-17F expression. [7]
          Interferon-22
             HIF ID HIFM0143 HIF Info       Class Cytokine (Cyt)
             Description The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-22 expression. [7]
          Interleukin-23 subunit alpha
             HIF ID HIFM0144 HIF Info       Class Cytokine (Cyt)
             Description The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-23 expression. [7]
          Interleukin-17E
             HIF ID HIFM0145 HIF Info       Class Cytokine (Cyt)
             Description The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-17E expression. [7]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Prevotella copri is associated with IFN-Gamma. [7]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Prevotella copri was associated with IgG response in rheumatoid arthritis disease. [7]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description IgA could response to Prevotella copri. [7]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description A 27-kD protein of Prevotella copri stimulated Th1 responses in some new-onset rheumatoid arthritis patients. [7]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Prevotella copri induced production of IgA antibody responses which correlated with serum levels of a range of cytokines and chemokines associated with innate Th17 immune responses. [7]
Environmental Factor(s)
             Disbiome ID
      18
             gutMDisorder ID
      gm0536
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
3 Analysis of Gut Microbiota in Patients with Parkinson's Disease. Bull Exp Biol Med. 2017 Apr;162(6):734-737. doi: 10.1007/s10517-017-3700-7. Epub 2017 Apr 20.
4 Distinct Genetic and Functional Traits of Human Intestinal Prevotella copri Strains Are Associated with Different Habitual Diets. Cell Host Microbe. 2019 Mar 13;25(3):444-453.e3. doi: 10.1016/j.chom.2019.01.004. Epub 2019 Feb 21.
5 Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium.Genome Biol. 2020 Mar 11;21(1):64. doi: 10.1186/s13059-020-01976-7.
6 Low Salivary Amylase Gene (AMY1) Copy Number Is Associated with Obesity and Gut Prevotella Abundance in Mexican Children and Adults.Nutrients. 2018 Nov 1;10(11):1607. doi: 10.3390/nu10111607.
7 Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 May;69(5):964-975. doi: 10.1002/art.40003. Epub 2017 Apr 7.

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