Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0135)
HIF Name
Interleukin-17F
HIF Synonym(s)
interleukin 17F, IL17F, ML1, ML-1, CANDF6
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description A gene on chromosome 6p12 that encodes IL-17F, a cytokine which stimulates the production of other cytokines (e.g., IL-6, IL-8 and granulocyte colony-stimulating factor) and regulates cartilage matrix turnover. [1]
Pfam Interleukin-17 (PF06083 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
IL-17 signaling pathway (hsa04657 )
Inflammatory bowel disease (IBD) (hsa05321 )
Th17 cell differentiation (hsa04659 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL17F_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Clostridium leptum (firmicutes) MIC00402
             Description Early-life Clostridium leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells, resulting in the inhibition of Th17 cell responses,which were characterized by IL-17F production. [2]
         Prevotella copri (CFB bacteria) MIC01010
             Description The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-17F expression. [3]
References
1 IL-17F expression correlates with clinicopathologic factors and biological markers in non-small cell lung cancer.Pathol Res Pract. 2019 Oct;215(10):152562. doi: 10.1016/j.prp.2019.152562. Epub 2019 Jul 31.
2 Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
3 Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 May;69(5):964-975. doi: 10.1002/art.40003. Epub 2017 Apr 7.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.