Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0143)
HIF Name
Interferon-22
HIF Synonym(s)
interleukin 22, IL22, TIFa, IL-21, ILTIF, IL-TIF, IL-D110, zcyto18, TIFIL-23
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description IL22 A gene on chromosome 12q15 that encodes interleukin-22, a cytokine which plays an uncertain role in the inflammatory response. [1]
Pfam Interleukin 22 IL-10-related T-cell-derived-inducible factor (PF14565 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Inflammatory bowel disease (IBD) (hsa05321 )
JAK-STAT signaling pathway (hsa04630 )
Th17 cell differentiation (hsa04659 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL22_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Lactobacillus sp. (firmicutes) MIC00701
             Description Lactobacilli produce an AhR ligand,which induces IL22 expression. [2]
         Prevotella copri (CFB bacteria) MIC01010
             Description The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-22 expression. [3]
References
1 Clinical importance of IL-22 cascade in IBD.J Gastroenterol. 2018 Apr;53(4):465-474. doi: 10.1007/s00535-017-1401-7. Epub 2017 Oct 26.
2 Microbiota and host immune responses: a love-hate relationship. Immunology. 2016 Jan;147(1):1-10. doi: 10.1111/imm.12538. Epub 2015 Nov 2.
3 Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 May;69(5):964-975. doi: 10.1002/art.40003. Epub 2017 Apr 7.

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