General Information of HIF (ID: HIFM0145)
HIF Name	Interleukin-17E
HIF Synonym(s)	interleukin 25, IL25
HIF Classification	Cytokine (Cyt)
Molecular Function	Cytokine
Description	Interleukin-17E (IL-17E), also commonly called IL-25, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F).				[1]
Pfam	Interleukin-17 (PF06083 )
Pathway	Cytokine-cytokine receptor interaction (hsa04060 )
	IL-17 signaling pathway (hsa04657 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	IL25_HUMAN

Microbe Species (MIC) Regulated by This HIF
Prevotella copri (CFB bacteria)			MIC01010
Description	The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-17E expression.				[2]

References
1	IL-17E (IL-25) Enhances Innate Immune Responses during Skin Inflammation.J Invest Dermatol. 2019 Aug;139(8):1732-1742.e17. doi: 10.1016/j.jid.2019.01.021. Epub 2019 Feb 6.
2	Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 May;69(5):964-975. doi: 10.1002/art.40003. Epub 2017 Apr 7.

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