| General Information of MIC (ID: MIC00269) |
| MIC Name |
Brucella canis (alpha-proteobacteria)
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| Body Site |
Blood
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| Lineage |
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Rhizobiales
Family: Brucellaceae
Genus: Brucella
Species: Brucella canis
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| Oxygen Sensitivity |
Aerobe
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| Microbial Metabolism |
Respiration
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| Gram |
Positive
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| Genome Size (bp) |
3310315
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| No. of Coding Genes |
2950
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| No. of Non-Coding Genes |
65
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| No. of Small Non-Coding Genes |
65
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| No. of Gene Transcripts |
3051
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| No. of Base Pairs |
3310315
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| Description |
Brucella canis is a Gram-negative proteobacterium in the family Brucellaceae that causes brucellosis in dogs and other canids. Humans can be also infected, but occurrences are rare.
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| External Links |
Taxonomy ID |
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| Genome Assembly ID |
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| GOLD Organism ID |
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| Host Immune Factors (HIFs) |
| Interleukin-17A |
| HIF ID |
HIFM0134 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
Brucella canis induced Th1/Th17 responses, with increased CD4+ T cells producing IL-17A simultaneously. |
[1] |
| Interferon gamma |
| HIF ID |
HIFM0260 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
The abundance of Brucella canis is associated with IFN-Gamma. |
[1] |
| CD4+ regulatory T cells |
| HIF ID |
HIFC0034 |
HIF Info
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Class |
T cells (TCs) |
| Description |
Brucella canis induces CD4+ T cells to produce multi-cytokine Th1/Th17 via dendritic cell activation. |
[1] |
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| Environmental Factor(s) |
| Disbiome ID |
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| References |
| 1 |
Brucella canis induces canine CD4(+) T cells multi-cytokine Th1/Th17 production via dendritic cell activation. Comp Immunol Microbiol Infect Dis. 2019 Feb;62:68-75. doi: 10.1016/j.cimid.2018.11.017. Epub 2018 Nov 30.
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