General Information of MIC (ID: MIC00915)
MIC Name	Nocardia farcinica (actinobacteria)
MIC Synonyms	Streptothrix farcinica
Body Site	Lung
Lineage	Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Corynebacteriales Family: Nocardiaceae Genus: Nocardia Species: Nocardia farcinica
Oxygen Sensitivity	Obligate aerobe
Microbial Metabolism	Glycolysis; TCA cycle
Gram	Positive
Host Relationship	Opportunistic pathogen
Genome Size (bp)	6459780
No. of Coding Genes	6122
No. of Non-Coding Genes	68
No. of Small Non-Coding Genes	68
No. of Gene Transcripts	6190
No. of Base Pairs	6459780
Description	Nocardia farcinica is an obligatlye aerobic, Gram positive, non motile bacterium. It is significant to modern medicine as it is a pathogen which threatens both human health and the health of important assets such as herds of cattle, horses and many other animals.
External Links	Taxonomy ID	37329
	Genome Assembly ID	NCTC11134
	GOLD Organism ID	Go0519041
Disease Relevance
Diseases of mediastinum  [ICD-11: GB22]
Description	Nocardia farcinica was associated with mediastinitis.				[1]
Pneumonia  [ICD-11: CA40]
Description	Nocardia farcinica was associated with pneumonia.				[1]

Host Immune Factors (HIFs)
Interferon-10
HIF ID	HIFM0128	HIF Info	Class	Cytokine (Cyt)
Description	The recombinant Nocardia farcinica Mce1E can stimulate spleen lymphocytes of Nocardia farcinica-infected mice,but it not can express IL-10.				[2]
Interferon-4
HIF ID	HIFM0149	HIF Info	Class	Cytokine (Cyt)
Description	Spleen cell production of IL-4 remained low following stimulation with recombinant Mce1E protein, with no statistically significant differences after Nocardia farcinica infection.				[2]
Interferon gamma
HIF ID	HIFM0260	HIF Info	Class	Cytokine (Cyt)
Description	Nocardia farcinica could stimulate the expression of IFN-Gamma.				[2]
CD56+ Natural Killer cells
HIF ID	HIFC0095	HIF Info	Class	Natural killer cells (NKCs)
Description	The NKp44, of which the induction involved mainly CD56+ NK cells, was able to bind Nocardia farcinica.				[3]

Environmental Factor(s)
Disbiome ID			653

References
1	A Case of Nocardia farcinica Pneumonia and Mediastinitis in an Immunocompetent Patient. Tuberc Respir Dis (Seoul). 2016 Apr;79(2):101-3. doi: 10.4046/trd.2016.79.2.101. Epub 2016 Mar 31.
2	Cloning, Expression, Invasion, and Immunological Reactivity of a Mammalian Cell Entry Protein Encoded by the mce1 Operon of Nocardia farcinica. Front Microbiol. 2017 Feb 22;8:281. doi: 10.3389/fmicb.2017.00281. eCollection 2017.
3	Direct binding of human NK cell natural cytotoxicity receptor NKp44 to the surfaces of mycobacteria and other bacteria.Infect Immun. 2008 Apr;76(4):1719-27. doi: 10.1128/IAI.00870-07. Epub 2008 Jan 22.

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