General Information of HIF (ID: HIFM0009)
HIF Name	B- and T-lymphocyte attenuator
HIF Synonym(s)	CD272, BTLA
HIF Classification	Checkpoint molecule (CM)
Molecular Function	Receptor
Description	BTLA is expressed on T cells to regulate responses to self-proteins.				[1]
Pfam	Immunoglobulin domain (PF00047 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	BTLA_HUMAN

Microbe Species (MIC) Regulated by This HIF
Bifidobacterium sp. (actinobacteria)			MIC00224
Description	The continuous high expression of BTLA on CD4+ T cells in bifidobacterium therapy group.				[2]
Citrobacter rodentium (enterobacteria)			MIC00366
Description	The expression of Btla-/- was not susceptible to mucosal Citrobacter rodentium infection				[3]
Clostridium butyricum (firmicutes)			MIC00388
Description	The continuous high expression of BTLA on CD4+ T cells in Live Clostridium butyricum therapy group.				[2]

References
1	Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2	Effects of clostridium butyricum and bifidobacterium on BTLA expression on CD4(+) T cells and lymphocyte differentiation in late preterm infants.Microb Pathog. 2016 Nov;100:112-118. doi: 10.1016/j.micpath.2016.09.008. Epub 2016 Sep 10.
3	HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System.Immune Netw. 2014 Apr;14(2):67-72. doi: 10.4110/in.2014.14.2.67. Epub 2014 Apr 21.

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