General Information of MIC (ID: MIC00506)
MIC Name	Dialister pneumosintes (firmicutes)
MIC Synonyms	Bacterium pneumosintes
Body Site	Oral Cavity
Lineage	Kingdom: Bacteria Phylum: Firmicutes Class: Negativicutes Order: Veillonellales Family: Veillonellaceae Genus: Dialister Species: Dialister pneumosintes
Oxygen Sensitivity	Obligate anaerobe
Microbial Metabolism	Nonfermentative
Gram	Negative
Genome Size (bp)	1274073
No. of Coding Genes	1164
No. of Non-Coding Genes	73
No. of Small Non-Coding Genes	73
No. of Gene Transcripts	1251
No. of Pseudogenes	14
No. of Base Pairs	1274073
Description	Dialister pneumosintes is an obligate anaerobic Gram-negative rod associated with infections of the oral cavity.
External Links	Taxonomy ID	39950
	Genome Assembly ID	ASM171750v1
	GOLD Organism ID	Go0487284
Disease Relevance
Chronic kidney disease  [ICD-11: GB61]
Description	Dialister was negatively correlated with CKD(Chronic kidney disease) severity.				[1]
Gastric cancer  [ICD-11: 2B72]
Description	Dialister pneumosintes had a porential role in Gastric cancer progression.				[2]
Inflammatory bowel disease  [ICD-11: DD72]
Description	Dialister was associated with inflammatory bowel disease.				[3]
Periodontal disease  [ICD-11: DA0C]
Description	Dialister pneumosintes was a candidate periodontal pathogen.				[4]
Spondyloarthritis  [ICD-11: FA92]
Description	Dialister may represent a potential microbial marker of disease activity in Spondyloarthritis.				[3]

Host Genetic Factors (HGFs)
rs12442649
HGF ID	HGF2194	HGF Info	Class	Single Nucleotide Polymorphism (SNP)
Description	The rs12442649 SNP was significantly associated with the abundance of Dialister (p-value=3.72E-8).				[5]

Host Immune Factors (HIFs)
CD4+ helper T cells
HIF ID	HIFC0068	HIF Info	Class	T cells (TCs)
Description	An increased levels of Dialister was accompanied by altered Th1/Th2 ratios.				[6]
T helper type 2 cells
HIF ID	HIFC0085	HIF Info	Class	T cells (TCs)
Description	An increased levels of Dialister was accompanied by a decrease in T-helper 2 (Th2) responses and altered Th1/Th2 ratios.				[6]

Environmental Factor(s)
Disbiome ID			299
gutMDisorder ID			gm0262

References
1	Gut Microbiota as Diagnostic Tools for Mirroring Disease Progression and Circulating Nephrotoxin Levels in Chronic Kidney Disease: Discovery and Validation Study. Int J Biol Sci. 2020 Jan 1;16(3):420-434. doi: 10.7150/ijbs.37421. eCollection 2020.
2	Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut. 2018 Jun;67(6):1024-1032. doi: 10.1136/gutjnl-2017-314281. Epub 2017 Aug 1.
3	Brief Report: Dialister as a Microbial Marker of Disease Activity in Spondyloarthritis. Arthritis Rheumatol. 2017 Jan;69(1):114-121. doi: 10.1002/art.39802. Epub 2016 Dec 1.
4	Dialister pneumosintes, a new putative periodontal pathogen. J Periodontal Res. 2002 Feb;37(1):75-8. doi: 10.1034/j.1600-0765.2002.05019.x.
5	Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.Nat Genet. 2016 Nov;48(11):1396-1406. doi: 10.1038/ng.3695. Epub 2016 Oct 10.
6	Host-bacterial interactions during induction and resolution of experimental gingivitis in current smokers. J Periodontol. 2013 Jan;84(1):32-40. doi: 10.1902/jop.2012.110662. Epub 2012 Mar 16.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.