Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00665)
MIC Name Helicobacter cinaedi (epsilon-proteobacteria)
MIC Synonyms Campylobacter cinaedi
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Helicobacteraceae
Genus: Helicobacter
Species: Helicobacter cinaedi
Oxygen Sensitivity Microaerophile
Microbial Metabolism Strictly respiratory; Asaccharolytic
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 2182709
Description Helicobacter cinaedi formerly known as Campylobacter cinaedi, is a species of microaerophilic, Gram negative pathogen bacterium. It can cause bacteraemia, diarrhea and focal colonic lesions in humans.
External Links Taxonomy ID
213
Genome Assembly ID
ASM15547v1
GOLD Organism ID
Go0496655
Disease Relevance
          Colon cancer  [ICD-11: 2B90]
             Description Both Helicobacter cinaedi and Helicobacter fennelliae caused bacteraemia, diarrhoea and focal colonic lesions. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Helicobacter cinaedi was associated with inflammatory bowel disease. [2]
          Irritable bowel syndrome  [ICD-11: DD91]
             Description Helicobacter cinaedi causes infections, such as bacteremia, diarrhea and cellulitis in mainly immunocompromised patients. [3]
          Meningococcal disease  [ICD-11: 1C1C]
             Description Helicobacter cinaedi has been implicated as a cause of bacteraemia in immunocompromised individuals. [4]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description The levels of IL-10 were lower in the colonization by the Helicobacter cinaedi mutant. [5]
          Immunoglobulin G2
             HIF ID HIFM0268 HIF Info       Class Immunoglobulin (Ig)
             Description IgG2a could response to Helicobacter cinaedi infection. [5]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description IgG1 could response to Helicobacter cinaedi infection. [5]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description IgG2 serological markers for Th1 responses were significantly increased in subjects infected with WT Helicobacter cinaedi compared with uninfected controls. [5]
          T helper type 2 cells
             HIF ID HIFC0085 HIF Info       Class T cells (TCs)
             Description IgG1 serological markers for Th2 responses were significantly increased in subjects infected with WT Helicobacter cinaedi compared with uninfected controls. [5]
Environmental Factor(s)
             Disbiome ID
      98
             gutMDisorder ID
      gm0364
References
1 Isolation and characterization of a novel Helicobacter species, Helicobacter jaachi sp. nov., from common marmosets (Callithrix jaachus). J Med Microbiol. 2015 Sep;64(9):1063-1073. doi: 10.1099/jmm.0.000113. Epub 2015 Jun 30.
2 Helicobacter cinaedi induced typhlocolitis in Rag-2-deficient mice. Helicobacter. 2015 Apr;20(2):146-55. doi: 10.1111/hel.12179. Epub 2014 Nov 8.
3 Multidrug Efflux Systems in Helicobacter cinaedi. Antibiotics (Basel). 2012 Nov 21;1(1):29-43. doi: 10.3390/antibiotics1010029.
4 Cutaneous manifestations of Helicobacter cinaedi: a review. Br J Dermatol. 2016 Jul;175(1):62-8. doi: 10.1111/bjd.14353. Epub 2016 Feb 18.
5 Alkyl hydroperoxide reductase is required for Helicobacter cinaedi intestinal colonization and survival under oxidative stress in BALB/c and BALB/c interleukin-10-/- mice. Infect Immun. 2012 Mar;80(3):921-8. doi: 10.1128/IAI.05477-11. Epub 2011 Dec 19.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.