Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01108)
MIC Name Rickettsia prowazekii (alpha-proteobacteria)
Body Site Skin
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Rickettsiales
Family: Rickettsiaceae
Genus: Rickettsia
Species: Rickettsia prowazekii
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory; Tricarboxylicacid (TCA) cycle
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 1111769
Description Rickettsia prowazekii is an aerobic, Gram-negative, and obligate intracellular parasitic bacterium that lacks flagellum involved in typhus fever in human.
External Links Taxonomy ID
782
Genome Assembly ID
ASM27726v1
GOLD Organism ID
Go0145331
Disease Relevance
          Typhus fever  [ICD-11: 1C30]
             Description Rickettsia prowazekii caused epidemic typhus. [1]
Host Immune Factors (HIFs)
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description When BALB/c mice (n = 6 per experimental condition) were infected with 105 live Rickettsia prowazekii organisms, TNF and RANTES transcripts were significantly ( p < 0.05) increased in liver , lungs, and brain, at day 3 and decreased at day 6. [2]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description Specific IgG1 could be detected at day 7 and increased up to day 21 during R. prowazekii infection. [2]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Macrophages can kill Rickettsia prowazekii in the protection of subjects against rickettsial infections. [2]
          Interferon signaling pathway
             HIF ID HIFP0011 HIF Info       Class Signaling pathway (SP)
             Description At the species level, Rickettsia prowazekii is associated with IFN signaling. [2]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Th1 response was associated with IgG2a/IgG2b isotype secretion during Rickettsia prowazekii infection. [2]
          T helper type 2 cells
             HIF ID HIFC0085 HIF Info       Class T cells (TCs)
             Description Th2 response was associated with IgG1 secretion during Rickettsia prowazekii infection. [2]
References
1 The History of Epidemic Typhus. Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.PoH-0010-2015.
2 A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus. Microbes Infect. 2007 Jun;9(7):898-906. doi: 10.1016/j.micinf.2007.03.008. Epub 2007 Mar 21.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.